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The Mediatory Effect of Inflammatory Markers on the Association Between a Body Shape Index and Body Roundness Index With Cardiometabolic Risk Factor in Overweight and Obese Women: A Cross-Sectional Study Publisher



Mirzababaei A1 ; Abaj F1 ; Khosravinia D2 ; Ghorbani M3 ; Valisoltani N4 ; Clark CCT5 ; Radmehr M2 ; Mirzaei K1
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Centre for Intelligent Healthcare, Coventry University, Coventry, United Kingdom

Source: Frontiers in Nutrition Published:2023


Abstract

Background: Obesity affects body composition and anthropometric measurements. A Body Shape Index (ABSI) and Body Roundness Index (BRI) are reportedly associated with an increased risk of cardiovascular disease. However, the relationship between ABSI, BRI, cardiometabolic factors, and inflammatory elements is not well-elucidated. Therefore, this study sought to examine the mediatory effect of inflammatory markers on the association between ABSI and BRI with cardiometabolic risk factors in overweight and obese women. Methods: This cross-sectional study was performed on 394 obese and overweight women. The typical food intake of individuals was assessed using a 147-item semi-quantitative Food Frequency Questionnaire (FFQ). Body composition was measured by bioelectrical impedance analysis (BIA). Biochemical parameters, such as inflammatory markers and anthropometric components, were also assessed. For each participant, all measurements were carried out on the same day. Result: There was a significant positive association between ABSI and AC and CRI.I in subjects with higher ABSI scores before and after adjustment (P < 0.05). In addition, there was a significant positive association between BRI and FBS, TC, TG, AIP, AC, CRI.I, CRI.II, and TyG in participants with higher BRI scores before and after adjustment (P < 0.05). We found that hs-CRP, PAI-1, MCP-1, TGF-β, and Galectin-3 were mediators of these relationships (P < 0.05). Conclusion: Inflammation can play an important role in the relationship between body shape indices and cardiometabolic risk factors among overweight and obese women. Copyright © 2023 Mirzababaei, Abaj, Khosravinia, Ghorbani, Valisoltani, Clark, Radmehr and Mirzaei.
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