Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study

Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study Publisher

Mortazaviderazkola S¹ ; Salavatiniasari M¹ ; Khojasteh H¹ ; Amiri O² ; Ghoreishi SM³

Show Affiliations

1. Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran
2. Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, United States
3. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cleaner Production Published:2017

Abstract

In the present study, magnetically Fe3O4/SiO2/hydroxyapatite (Fe3O4/SiO2/HAp) nanocomposites were synthesized and modified with 3-aminopropyl triethoxysilane (APTES) using fructose as a green capping agent. The effect of different capping agent (such as fructose and glucose) and calcination temperature were investigated to reach optimum condition. The as-prepared nanocomposites were characterized by XRD, FT-IR, SEM, EDS, TEM, DLS, VSM and N2 adsorption-desorption isotherm technique. The as-prepared nanocomposites have been used as atenolol controlled carrier due to their advantage such as high pore size (13.37 nm) and large surface area (55.88 m2 g-1). The drug release was studied in the gastrointestinal tract (intestine and stomach) pH-similar milieu. The results show that 100% and 15.6% of impregnated atenolol could be released from Fe3O4/SiO2/HAp functionalized with APTES after 30 h at pH = 6.8 and pH 1.2, respectively. Also, the histopathological experiment shows that abnormality of the liver, spleen and kidney was observed after 48 h study. © 2017 Elsevier Ltd

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Hamid Akbari Javar (2)

Mehdi Shafee Ardestani (1)

Style	Citing Format
MLA	Mortazaviderazkola S, et al.. "Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study." Journal of Cleaner Production, vol. 168, no. , 2017, pp. 39-50.
APA	Mortazaviderazkola S, Salavatiniasari M, Khojasteh H, Amiri O, Ghoreishi SM (2017). Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study. Journal of Cleaner Production, 168(), 39-50.
Chicago	Mortazaviderazkola S, Salavatiniasari M, Khojasteh H, Amiri O, Ghoreishi SM. "Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study." Journal of Cleaner Production 168, no. (2017): 39-50.
Harvard	Mortazaviderazkola S et al. (2017) 'Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study', Journal of Cleaner Production, 168(), pp. 39-50.
Vancouver	Mortazaviderazkola S, Salavatiniasari M, Khojasteh H, Amiri O, Ghoreishi SM. Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study. Journal of Cleaner Production. 2017;168():39-50.
BibTex	@article{ author = {Mortazaviderazkola S and Salavatiniasari M and Khojasteh H and Amiri O and Ghoreishi SM}, title = {Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study}, journal = {Journal of Cleaner Production}, volume = {168}, number = {}, pages = {39-50}, year = {2017} }
RIS	TY - JOUR AU - Mortazaviderazkola S AU - Salavatiniasari M AU - Khojasteh H AU - Amiri O AU - Ghoreishi SM TI - Green Synthesis of Magnetic Fe3o4/Sio2/Hap Nanocomposite for Atenolol Delivery and in Vivo Toxicity Study JO - Journal of Cleaner Production VL - 168 IS - SP - 39 EP - 50 PY - 2017 ER -

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