Nanorobots in Dentistry: Current Applications and Future Prospects Publisher



Zarabadi MS ; Najari S ; Tayebi G ; Farzanegan P ; Nouri A
Source: Applications of Nanomaterials in Dentistry Published:2025

Abstract

Nanorobots, nanoscale devices engineered to operate at atomic, molecular, and cellular levels, present transformative possibilities for both medicine and dentistry. These highly advanced, yet largely conceptual, machines are envisioned to execute complex tasks, such as precise drug delivery and pathogen elimination, with unparalleled accuracy and efficiency. In medicine, nanorobots hold the promise of revolutionizing disease treatment, particularly in cancer therapies, by selectively targeting diseased cells while minimizing adverse side effects. Similarly, in dentistry, nanorobots are set to improve the precision and efficacy of various procedures, including pain management, tooth realignment, and tissue repair, offering minimally invasive and highly effective solutions. These innovations could enable early disease detection and more sophisticated treatments, leading to enhanced patient outcomes and a higher standard of care in dental practice. However, despite these promising prospects, several hurdles must be addressed before nanorobots can be fully integrated into clinical practice. Key challenges include the high cost of design and manufacturing, ensuring biocompatibility, navigating ethical considerations, and establishing regulatory frameworks for clinical use. Nanodentistry could revolutionize dental care through innovations such as painless anesthesia, targeted bacterial control, and advanced orthodontic and prosthodontic solutions. As research continues, nanorobots are expected to integrate with emerging technologies, such as tissue engineering and advanced drug delivery systems, expanding their role in healthcare. Overcoming these current limitations and addressing societal concerns will be critical to realizing the full potential of nanorobots, ushering in a new era of personalized, efficient healthcare solutions. © 2026 Elsevier Inc. All rights reserved.