Nanoengineered Drug Delivery Systems for Post-Orthodontic Surgical Care Publisher



Soleimani M ; Saeidi N ; Kani SSM ; Amirkhani A ; Mirkhani MS ; Mirmohammadi SMM ; Bathaei Y
Source: Nanomedicine Research Journal Published:2025

Abstract

Post-orthodontic surgical procedures frequently encounter complications such as pain, inflammation, infection, edema, and delayed wound healing, which can compromise treatment outcomes and patient comfort. This review examines the promising role of nanoengineered drug delivery systems (DDS) in addressing these challenges by enhancing targeted drug delivery, improving bioavailability, and enabling controlled release of therapeutic agents. Various nanoparticle platforms—including liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles, solid lipid nanoparticles, and calcium phosphate nanoclusters—are evaluated for their unique properties and applications in promoting tissue regeneration, preventing infection, and improving implant integration in post-orthodontic care. Despite substantial advancements, the clinical translation of nano-DDS faces hurdles related to scalability, safety, regulatory approval, and long-term biocompatibility. Future perspectives emphasize interdisciplinary research, the use of biodegradable materials, and the application of artificial intelligence to optimize nanocarrier design and personalize treatment strategies. Overall, nanoengineered DDS offer significant potential to revolutionize post-orthodontic surgical care by improving therapeutic efficacy and patient outcomes, underscoring the need for further clinical studies to fully realize their benefits in routine practice. © 2025 Elsevier B.V., All rights reserved.