Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?

Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends? Publisher Pubmed

Razavi AS^{1, 2} ; Mohtashami M^{2, 3} ; Razi S^{1, 2, 4} ; Rezaei N^{2, 5, 6}

Show Affiliations

1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
4. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden

Source: Cytokine Published:2022

Abstract

T-cells, as the main immune cells in fighting against cancer cells, are usually overwhelmed by many factors. Tumor microenvironment (TME) changes are one of the factors that can limit T-cells functions. On the other hand, platelets which are known as the main source of transforming growth factor-β (TGF-β) in TME, are seemingly insignificant immune cells that can affect T-cell functions. There is a hypothesis that platelets might prevent tumor growth by stimulating cellular immunity, especially T-cells in pre-cancer status while they can inhibit T-cells and stimulate tumor growth in the advanced stage of cancer. Therefore, platelets could act as a double-edged sword in the activation of T-cells under pre-cancer and advanced stages of cancer conditions. In this review, the interaction between platelets and T cells in pre-cancer and advanced stages of cancer and the role of TGF-β signaling in different stages of cancer will be discussed. © 2021 Elsevier Ltd

2. Tumor-Educated Platelets, Clinica Chimica Acta (2024)

3. The Molecular Mechanism of Actions and Clinical Utilities of Tumor Infiltrating Lymphocytes in Gastrointestinal Cancers: A Comprehensive Review and Future Prospects Toward Personalized Medicine, Frontiers in Immunology (2023)

4. Dysregulated Mirnas Network in the Critical Covid-19: An Important Clue for Uncontrolled Immunothrombosis/Thromboinflammation, International Immunopharmacology (2022)

5. Mesenchymal Stem Cell-Derived Antimicrobial Peptides As Potential Anti-Neoplastic Agents: New Insight Into Anticancer Mechanisms of Stem Cells and Exosomes, Frontiers in Cell and Developmental Biology (2022)

Style	Citing Format
MLA	Razavi AS, et al.. "Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?." Cytokine, vol. 150, no. , 2022, pp. -.
APA	Razavi AS, Mohtashami M, Razi S, Rezaei N (2022). Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?. Cytokine, 150(), -.
Chicago	Razavi AS, Mohtashami M, Razi S, Rezaei N. "Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?." Cytokine 150, no. (2022): -.
Harvard	Razavi AS et al. (2022) 'Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?', Cytokine, 150(), pp. -.
Vancouver	Razavi AS, Mohtashami M, Razi S, Rezaei N. Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?. Cytokine. 2022;150():-.
BibTex	@article{ author = {Razavi AS and Mohtashami M and Razi S and Rezaei N}, title = {Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends?}, journal = {Cytokine}, volume = {150}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Razavi AS AU - Mohtashami M AU - Razi S AU - Rezaei N TI - Tgf-Β Signaling and the Interaction Between Platelets and T-Cells in Tumor Microenvironment: Foes or Friends? JO - Cytokine VL - 150 IS - SP - EP - PY - 2022 ER -

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Abstract