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Understanding the Tumor Microenvironment for Effective Immunotherapy Publisher Pubmed



Sadeghi Rad H1 ; Monkman J2, 3 ; Warkiani ME4, 5 ; Ladwa R6 ; Obyrne K2, 3, 6 ; Rezaei N1, 7, 8 ; Kulasinghe A2, 3, 9
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
  3. 3. Translational Research Institute, Woolloongabba, QLD, Australia
  4. 4. School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW, Australia
  5. 5. Institute of Molecular Medicine, Sechenov University, Moscow, Russian Federation
  6. 6. Princess Alexandra Hospital, Woolloongabba, QLD, Australia
  7. 7. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Network of Immunity in Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Tehran, Iran
  9. 9. Institute for Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia

Source: Medicinal Research Reviews Published:2021


Abstract

Advances in immunotherapy have led to durable and long-term benefits in a subset of patients across a number of solid tumor types. Understanding of the subsets of patients that respond to immune checkpoint inhibitors at the cellular level, and in the context of their tumor microenvironment (TME) is becoming increasingly important. The TME is composed of a heterogeneous milieu of tumor and immune cells. The immune landscape of the TME can inhibit or promote tumor initiation and progression; thus, a deeper understanding of tumor immunity is necessary to develop immunotherapeutic strategies. Recent developments have focused on characterizing the TME immune contexture (type, density, and function) to discover mechanisms and biomarkers that may predict treatment outcomes. This has, in part, been powered by advancements in spatial characterization technologies. In this review article, we address the role of specific immune cells within the TME at various stages of tumor progression and how the immune contexture determinants affecting tumor growth are used therapeutically. © 2020 The Authors. Medicinal Research Reviews published by Wiley Periodicals LLC
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