A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride

A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride Publisher

Mahdavi M¹ ; Hassanzadeh R² ; Soheilizad M² ; Golshani S² ; Moghimi S² ; Firoozpour L¹ ; Shafiee A² ; Foroumadi A^{1, 2}

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1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Tetrahedron Letters Published:2016

Abstract

A novel and straightforward method for the synthesis of quinazolin-4(3H)-ones is described. The one-pot reaction between isatoic anhydride and (het)arylmethanamines led to the formation of N-substituted anthranilamides, which under aerobic conditions in the presence of CuBr undergo an in situ oxidation–cyclization reaction to produce quinazolin-4(3H)-ones in good yields. © 2016 Elsevier Ltd

Style	Citing Format
MLA	Mahdavi M, et al.. "A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride." Tetrahedron Letters, vol. 57, no. 33, 2016, pp. 3770-3772.
APA	Mahdavi M, Hassanzadeh R, Soheilizad M, Golshani S, Moghimi S, Firoozpour L, Shafiee A, Foroumadi A (2016). A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride. Tetrahedron Letters, 57(33), 3770-3772.
Chicago	Mahdavi M, Hassanzadeh R, Soheilizad M, Golshani S, Moghimi S, Firoozpour L, Shafiee A, Foroumadi A. "A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride." Tetrahedron Letters 57, no. 33 (2016): 3770-3772.
Harvard	Mahdavi M et al. (2016) 'A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride', Tetrahedron Letters, 57(33), pp. 3770-3772.
Vancouver	Mahdavi M, Hassanzadeh R, Soheilizad M, Golshani S, Moghimi S, Firoozpour L, et al.. A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride. Tetrahedron Letters. 2016;57(33):3770-3772.
BibTex	@article{ author = {Mahdavi M and Hassanzadeh R and Soheilizad M and Golshani S and Moghimi S and Firoozpour L and Shafiee A and Foroumadi A}, title = {A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride}, journal = {Tetrahedron Letters}, volume = {57}, number = {33}, pages = {3770-3772}, year = {2016} }
RIS	TY - JOUR AU - Mahdavi M AU - Hassanzadeh R AU - Soheilizad M AU - Golshani S AU - Moghimi S AU - Firoozpour L AU - Shafiee A AU - Foroumadi A TI - A Novel and Efficient Synthesis of 2-Substituted Quinazolin-4(3H)-Ones by the Reaction of (Het)Arylmethanamines With Isatoic Anhydride JO - Tetrahedron Letters VL - 57 IS - 33 SP - 3770 EP - 3772 PY - 2016 ER -

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