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Green Synthesis of 2-((2-Aryl-3-Oxoisoindolin-1-Yl)Methyl)Quinazolin-4(3H)-Ones Via Sequential Condensation, Sp3 C–H Bond Functionalization and Cyclization Publisher



Tashrifi Z1 ; Radmoghadam K1 ; Mehrdad M1 ; Soheilizad M2 ; Larijani B3 ; Mahdavi M3
Authors

Source: Tetrahedron Letters Published:2018


Abstract

A novel and green synthesis of 2-((2-aryl-3-oxoisoindolin-1-yl)methyl)quinazolin-4(3H)-one is described. The one-pot three-component reaction between 2-methylquinazolin-4(3H)-ones, aryl amines and 2-formylbenzoic acid, through a sequential condensation, sp3 C–H bond functionalization and cyclization reactions in aqueous media leads to formation of desired compounds in good to excellent yields. © 2018 Elsevier Ltd
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