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Targeted Anti-Mitochondrial Therapy: The Future of Oncology Publisher Pubmed



Taghizadehhesary F1, 2 ; Akbari H3, 4 ; Bahadori M5 ; Behnam B6
Authors
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Authors Affiliations
  1. 1. ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, 1445613131, Iran
  2. 2. Department of Radiation Oncology, Iran University of Medical Sciences, Tehran, 1445613131, Iran
  3. 3. Department of Pathology, Shahid Beheshti University of Medical Sciences, P.O. Box 4739-19395, Tehran, Iran
  4. 4. Traditional Medicine School, Tehran University of Medical Sciences, P.O. Box 14155-6559, Tehran, Iran
  5. 5. Faculty of Medicine, Tehran University of Medical Sciences, P.O. Box 14155-6559, Tehran, Iran
  6. 6. Department of Regulatory Affairs, Amarex Clinical Research, Germantown, 20874, MD, United States

Source: Genes Published:2022


Abstract

Like living organisms, cancer cells require energy to survive and interact with their environment. Mitochondria are the main organelles for energy production and cellular metabolism. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the cancer puzzle, the dependence on the normal cells. This article illustrates the benefits of new functional mitochondria for cancer cells that urge them to hijack mitochondria. It describes how functional mitochondria help cancer cells’ survival in the harsh tumor microenvironment, immune evasion, progression, and treatment resistance. Recent evidence has put forward the pivotal role of mitochondria in the metabolism of cancer stem cells (CSCs), the tumor components responsible for cancer recurrence and metastasis. This theory highlights the mitochondria in cancer biology and explains how targeting mitochondria may improve oncological outcomes. © 2022 by the authors.
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