The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects

The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects Publisher Pubmed

Marvasti FE^{1, 2} ; Moshiri A^{3, 4} ; Taghavi MS² ; Riazi S² ; Taati M² ; Sadati SF² ; Ghaheri A⁵ ; Masoomi M^{1, 6} ; Vaziri F^{1, 6} ; Fateh A^{1, 6} ; Rohani P^{7, 9} ; Tarashi S¹ ; Masotti A⁸ ; Badi SA¹ Show All Authors

Marvasti FE^{1, 2}
Moshiri A^{3, 4}
Taghavi MS²
Riazi S²
Taati M²
Sadati SF²
Ghaheri A⁵
Masoomi M^{1, 6}
Vaziri F^{1, 6}
Fateh A^{1, 6}
Rohani P^{7, 9}
Tarashi S¹
Masotti A⁸
Badi SA¹
Siadat SD^{1, 6, 7, 9}

Show Affiliations

1. Microbiology Research Centre, Pasteur Institute of Iran, Tehran, Iran
2. The Islamic Azad University, Science and Research Branch, Tehran, Iran
3. Research Centre for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy
5. Departments of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
6. Mycobacteriology and Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran
7. Department of Pediatric Gastroentrology and Hepatology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Research Laboratories, Bambino Gesu Children's Hospital-IRCCS, Rome, Italy
9. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Biomedical Journal Published:2020

Abstract

Background: Obesity is a complex disorder influenced by various genetic and environmental factors. It has been shown that gut microbiota, which colonizes gastrointestinal tract, has a substantial role as an environmental factor in the pathophysiology of obesity. Since the composition of gut microbiota alters with regard to different criteria, such as ethnicity, geographical location, diet, lifestyle, age, and gender, we aimed to determine F/B ratio and the abundance of important gut microbiota members, A. muciniphila, F. prausnitzii, Roseburia, Bifidobacterium, and Prevotella in Iranian obese and normal weight individuals, for the first time. Methods: In this study, 50 normal and 50 obese subjects were recruited and classified based on their BMI into normal weight and obese groups. Stool samples were collected. Following DNA extraction from the samples, qPCR was conducted based on 16s rDNA universal primers. Finally, the correlation between the bacterial abundance and obesity was analyzed by statistical analyses. Results: We observed a significant increase of F/B ratio in the obese group, compared to the normal weight group (p = 0.002). Although A. muciniphila (p = 0.039) and Bifidobacterium (p = 0.049) abundance significantly decreased, the abundance of F. prausnitzii (p = 0.046) significantly elevated with BMI increase in the studied groups. Conclusion: Owing to the importance of the gut microbiota composition in obesity development, determination and targeted restoration of gut microbiota pattern could be valuable in the control and treatment of obesity in certain populations. DOI: 10.29252/ibj.24.3.148. © 2020, Pasteur Institute of Iran. All rights reserved.

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Style	Citing Format
MLA	Marvasti FE, et al.. "The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects." Iranian Biomedical Journal, vol. 24, no. 3, 2020, pp. 148-154.
APA	Marvasti FE, Moshiri A, Taghavi MS, Riazi S, Taati M, Sadati SF, Ghaheri A, Masoomi M, Vaziri F, Fateh A, Rohani P, Tarashi S, Masotti A, Badi SA, Siadat SD (2020). The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects. Iranian Biomedical Journal, 24(3), 148-154.
Chicago	Marvasti FE, Moshiri A, Taghavi MS, Riazi S, Taati M, Sadati SF, Ghaheri A, et al.. "The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects." Iranian Biomedical Journal 24, no. 3 (2020): 148-154.
Harvard	Marvasti FE et al. (2020) 'The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects', Iranian Biomedical Journal, 24(3), pp. 148-154.
Vancouver	Marvasti FE, Moshiri A, Taghavi MS, Riazi S, Taati M, Sadati SF, et al.. The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects. Iranian Biomedical Journal. 2020;24(3):148-154.
BibTex	@article{ author = {Marvasti FE and Moshiri A and Taghavi MS and Riazi S and Taati M and Sadati SF and Ghaheri A and Masoomi M and Vaziri F and Fateh A and Rohani P and Tarashi S and Masotti A and Badi SA and Siadat SD}, title = {The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects}, journal = {Iranian Biomedical Journal}, volume = {24}, number = {3}, pages = {148-154}, year = {2020} }
RIS	TY - JOUR AU - Marvasti FE AU - Moshiri A AU - Taghavi MS AU - Riazi S AU - Taati M AU - Sadati SF AU - Ghaheri A AU - Masoomi M AU - Vaziri F AU - Fateh A AU - Rohani P AU - Tarashi S AU - Masotti A AU - Badi SA AU - Siadat SD TI - The First Report of Differences in Gut Microbiota Composition Between Obese and Normal Weight Iranian Subjects JO - Iranian Biomedical Journal VL - 24 IS - 3 SP - 148 EP - 154 PY - 2020 ER -

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