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Autoimmunity Roots of the Thrombotic Events After Covid-19 Vaccination Publisher Pubmed



Elrashdy F1 ; Tambuwala MM2 ; Hassan SS3 ; Adadi P4 ; Seyran M5 ; Abd Elaziz TM6, 7 ; Rezaei N8, 9 ; Lal A10 ; Aljabali AAA11 ; Kandimalla R12, 13 ; Bazan NG14 ; Azad GK15 ; Sherchan SP16 ; Choudhury PP17 Show All Authors
Authors
  1. Elrashdy F1
  2. Tambuwala MM2
  3. Hassan SS3
  4. Adadi P4
  5. Seyran M5
  6. Abd Elaziz TM6, 7
  7. Rezaei N8, 9
  8. Lal A10
  9. Aljabali AAA11
  10. Kandimalla R12, 13
  11. Bazan NG14
  12. Azad GK15
  13. Sherchan SP16
  14. Choudhury PP17
  15. Serranoaroca A18
  16. Takayama K19
  17. Chauhan G20
  18. Pizzol D21
  19. Barh D22
  20. Panda PK23
  21. Mishra YK24
  22. Palu G25
  23. Lundstrom K26
  24. Redwan EM27
  25. Uversky VN28
Show Affiliations
Authors Affiliations
  1. 1. Department of Endemic Medicine and Hepatogastroenterology, Kasr Alainy, Cairo University, Cairo, Egypt
  2. 2. School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, United Kingdom
  3. 3. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, Paschim Medinipur, 722140, West Bengal, India
  4. 4. Department of Food Science, University of Otago, Dunedin, New Zealand
  5. 5. Doctoral Student in Natural and Technical Sciences (SPL 44), University of Vienna, Wahringer Straße, Vienna, A-1090, Austria
  6. 6. Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt
  7. 7. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, 78229-3900, TX, United States
  8. 8. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden
  10. 10. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, United States
  11. 11. Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, P. O. BOX 566, Irbid, 21163, Jordan
  12. 12. Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad, 500007, India
  13. 13. Department of Biochemistry, Kakatiya Medical College, Warangal, India
  14. 14. Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, Louisiana, 70112, United States
  15. 15. Department of Zoology, Patna University, Patna, 800005, Bihar, India
  16. 16. Department of Environmental Health Sciences, Tulane University, New Orleans, 70112, LA, United States
  17. 17. Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India
  18. 18. Biomaterials and Bioengineering Lab, Centro de Investigacion Traslacional San Alberto Magno, Universidad Catolica de Valencia San Vicente Martir, c/Guillem de Castro 94, 46001, Valencia, Spain
  19. 19. Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8397, Japan
  20. 20. School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Monterrey, 64849, Nuevo Leon, Mexico
  21. 21. Italian Agency for Development Cooperation -, Khartoum, Sudan Street 33, Al Amarat, Sudan
  22. 22. Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB-721172, India
  23. 23. Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, Uppsala, SE-751 20, Sweden
  24. 24. University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, Sonderborg, 6400, Denmark
  25. 25. Department of Molecular Medicine, University of Padova, Italy
  26. 26. PanTherapeutics, Lutry, Switzerland
  27. 27. Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
  28. 28. Department of Molecular Medicine, University of South Florida, Tampa, FL, United States

Source: Autoimmunity Reviews Published:2021


Abstract

Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition. © 2021 Elsevier B.V.
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