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Covid-19 Vaccines and Thrombosis—Roadblock or Dead-End Street? Publisher Pubmed



Lundstrom K1 ; Barh D2, 3 ; Uhal BD4 ; Takayama K5 ; Aljabali AAA6 ; Abd Elaziz TM7, 8 ; Lal A9 ; Redwan EM10 ; Adadi P11 ; Chauhan G12 ; Sherchan SP13 ; Azad GK14 ; Rezaei N15, 16 ; Serranoaroca A17 Show All Authors
Authors
  1. Lundstrom K1
  2. Barh D2, 3
  3. Uhal BD4
  4. Takayama K5
  5. Aljabali AAA6
  6. Abd Elaziz TM7, 8
  7. Lal A9
  8. Redwan EM10
  9. Adadi P11
  10. Chauhan G12
  11. Sherchan SP13
  12. Azad GK14
  13. Rezaei N15, 16
  14. Serranoaroca A17
  15. Bazan NG18
  16. Hassan SS19
  17. Panda PK20
  18. Choudhury PP21
  19. Pizzol D22
  20. Kandimalla R23, 24
  21. Baetasdacruz W25
  22. Mishra YK26
  23. Palu G27
  24. Brufsky AM28
  25. Tambuwala MM29
  26. Uversky VN30
Show Affiliations
Authors Affiliations
  1. 1. PanTherapeutics, Lutry, CH 1095, Switzerland
  2. 2. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Purba Medinipur, 721172, India
  3. 3. Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Brazil
  4. 4. Department of Physiology, Michigan State University, East Lansing, 48824, MI, United States
  5. 5. Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8397, Japan
  6. 6. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, P. O. BOX 566, Irbid, 21163, Jordan
  7. 7. Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt
  8. 8. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, 78229, TX, United States
  9. 9. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, 55902, MN, United States
  10. 10. Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
  11. 11. Department of Food Science, University of Otago, Dunedin, 9054, New Zealand
  12. 12. School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Monterrey, 64849, Mexico
  13. 13. Department of Environmental Health Sciences, Tulane University, New Orleans, 70112, LA, United States
  14. 14. Department of Zoology, Patna University, Patna, 800005, India
  15. 15. Research Center for Immunodeficiency, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  16. 16. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, 17177, Sweden
  17. 17. Biomaterials and Bioengineering Lab, Centro de Investigacion Traslacional San Alberto Magno, Universidad Catolica de Valencia San Vicente Martir, c/Guillem de Castro 94, Valencia, 46001, Spain
  18. 18. Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, 70112, LA, United States
  19. 19. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India
  20. 20. Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, Uppsala, 75120, Sweden
  21. 21. Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, India
  22. 22. Italian Agency for Development Cooperation—Khartoum, Sudan Street 33, Al Amarat, 11111, Sudan
  23. 23. Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad, 500007, India
  24. 24. Department of Biochemistry, Kakatiya Medical College, Warangal, 506007, India
  25. 25. Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-901, Brazil
  26. 26. Mads Clausen Institute, University of Southern Denmark, NanoSYD, Alsion 2, Sonderborg, 6400, Denmark
  27. 27. Department of Molecular Medicine, University of Padova, PD, Padova, 35122, Italy
  28. 28. UPMC Hillman Cancer Center, Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, 15213, PA, United States
  29. 29. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, BT52 1SA, United Kingdom
  30. 30. Department of Molecular Medicine, USF Health Byrd Alzheimer’s Institute, Morsani College of Medicine, University of South Florida, Tampa, 33612, FL, United States

Source: Biomolecules Published:2021


Abstract

Two adenovirus-based vaccines, ChAdOx1 nCoV-19 and Ad26.COV2.S, and two mRNA-based vaccines, BNT162b2 and mRNA.1273, have been approved by the European Medicines Agency (EMA), and are invaluable in preventing and reducing the incidence of coronavirus disease-2019 (COVID-19). Recent reports have pointed to thrombosis with associated thrombocytopenia as an adverse effect occurring at a low frequency in some individuals after vaccination. The causes of such events may be related to SARS-CoV-2 spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans (HSPGs) and the CD147 receptor, or to different soluble splice variants of the spike protein, adenovirus vector interactions with the CD46 receptor or platelet factor 4 antibodies. Similar findings have been reported for several viral diseases after vaccine administration. In addition, immunological mechanisms elicited by viral vectors related to cellular delivery could play a relevant role in individuals with certain genetic backgrounds. Although rare, the potential COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) requires immediate validation, especially in risk groups, such as the elderly, chronic smokers, and individuals with pre-existing incidences of thrombocytopenia; and if necessary, a reformulation of existing vaccines. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.