Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass

Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass Publisher

Solgi S¹ ; Khakbiz M¹ ; Shahrezaee M² ; Zamanian A³ ; Tahriri M^{4, 5, 6} ; Keshtkari S⁷ ; Raz M⁶ ; Khoshroo K⁵ ; Moghadas S⁸ ; Rajabnejad A¹

Show Affiliations

1. Faculty of New Science and Technologies, University of Tehran, Tehran, Iran
2. Orthopedic Surgery Department, AJA University of Medical Science, Tehran, Iran
3. Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran
4. Iranian Tissue Bank & Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran
5. Dental Biomaterials Department, School of Dentistry, Tehran University of Medical Sciences (TUMS), Tehran, Iran
6. Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
7. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Ceramic Department, Materials and Energy Research Center, Karaj, Iran

Source: Silicon Published:2017

Abstract

In this study, bioactive glass of the type SiO2–CaO–SrO–P2O5 was obtained by the sol-gel processing method and the effects of SrO/CaO substitution on the in vitro biological properties of the synthesized glasses were evaluated. The obtained bioactive glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), differentioal scanning caloremetry (DSC) and Brunauer, Emmett and Teller (BET) analyses. The effects of various glass compositions on proliferation and differentiation of osteoblastic cells were also evaluated. The results showed that incorporation of Sr in the obtained glass network did not result in any structural alteration due to the similar role of SrO compared with that of CaO. In vitro experiments with human osteosarcoma cell lines (MG-63) indicated that bioactive glass incorporating 5 mol % in the composition revealed optimal cell proliferation and alkaline phosphatase (ALP) activity. Our results ascertained this material to be non-toxic and compatible for the proposed work in segmental defects in the rabbit model in vivo. © 2015, Springer Science+Business Media Dordrecht.

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Style	Citing Format
MLA	Solgi S, et al.. "Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass." Silicon, vol. 9, no. 4, 2017, pp. 535-542.
APA	Solgi S, Khakbiz M, Shahrezaee M, Zamanian A, Tahriri M, Keshtkari S, Raz M, Khoshroo K, Moghadas S, Rajabnejad A (2017). Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass. Silicon, 9(4), 535-542.
Chicago	Solgi S, Khakbiz M, Shahrezaee M, Zamanian A, Tahriri M, Keshtkari S, Raz M, Khoshroo K, Moghadas S, Rajabnejad A. "Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass." Silicon 9, no. 4 (2017): 535-542.
Harvard	Solgi S et al. (2017) 'Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass', Silicon, 9(4), pp. 535-542.
Vancouver	Solgi S, Khakbiz M, Shahrezaee M, Zamanian A, Tahriri M, Keshtkari S, et al.. Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass. Silicon. 2017;9(4):535-542.
BibTex	@article{ author = {Solgi S and Khakbiz M and Shahrezaee M and Zamanian A and Tahriri M and Keshtkari S and Raz M and Khoshroo K and Moghadas S and Rajabnejad A}, title = {Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass}, journal = {Silicon}, volume = {9}, number = {4}, pages = {535-542}, year = {2017} }
RIS	TY - JOUR AU - Solgi S AU - Khakbiz M AU - Shahrezaee M AU - Zamanian A AU - Tahriri M AU - Keshtkari S AU - Raz M AU - Khoshroo K AU - Moghadas S AU - Rajabnejad A TI - Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass JO - Silicon VL - 9 IS - 4 SP - 535 EP - 542 PY - 2017 ER -

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