Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synthesis, Physico-Chemical and Biological Characterization of Strontium and Cobalt Substituted Bioactive Glasses for Bone Tissue Engineering Publisher



Kargozar S1 ; Lotfibakhshaiesh N1 ; Ai J1 ; Samadikuchaksaraie A2, 3, 4 ; Hill RG5 ; Shah PA6 ; Milan PB1 ; Mozafari M2, 3, 7 ; Fathi M8 ; Joghataei MT1, 2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom
  6. 6. The London School of Medicine and Dentistry, Institute of Dentistry, London, United Kingdom
  7. 7. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  8. 8. Biomaterials Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran

Source: Journal of Non-Crystalline Solids Published:2016


Abstract

Due to their vast potential for repair and regeneration, different types of bioactive glasses (BGs) have been widely studied for bone tissue engineering. In this study, different groups of melt-derived bioactive glasses containing strontium (Sr2 +) and cobalt (Co2 +) ions have been designed to investigate their potential effect on increasing cell osteogenic activity. After full characterization of the synthesized bioactive glasses, they were evaluated for apatite forming ability in simulated body fluid (SBF) after different time intervals. The glasses have been examined for cell attachment and cell cytotoxicity plus their influence on osteogenic activity of the cells was analyzed by alkaline phosphatase assay (ALP) and alizarin red staining. The results show that the samples are in glassy state before immersion in SBF and an apatite-like layer has formed on the surface of SBF-immersed samples after 3, 7 and 14 days. In vitro experiments demonstrated that the incorporation of Sr2 + and Co2 + in the glass composition significantly promote osteogenic activity of human osteosarcoma cells without any cytotoxicity effect. © 2016 Elsevier B.V.
Related Docs
View other Related Docs
1. Strontium- and Cobalt-Substituted Bioactive Glasses Seeded With Human Umbilical Cord Perivascular Cells to Promote Bone Regeneration Via Enhanced Osteogenic and Angiogenic Activities, Acta Biomaterialia (2017)
2. Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering, Trends in Biotechnology (2018)
3. Bioactive Glasses: Where Are We and Where Are We Going?, Journal of Functional Biomaterials (2018)
4. Synthesis and Characterization of Novel Mesoporous Strontium-Modified Bioactive Glass Nanospheres for Bone Tissue Engineering Applications, Microporous and Mesoporous Materials (2020)
5. Stimulation of Osteogenic Differentiation of Induced Pluripotent Stem Cells (Ipscs) Using Bioactive Glasses: An in Vitro Study, Frontiers in Bioengineering and Biotechnology (2019)
6. Effects of the Biological Environment on Ceramics: Degradation, Cell Response, and in Vivo Behavior, Fundamental Biomaterials: Ceramics (2018)
7. Osteogenic Potential of Stem Cells-Seeded Bioactive Nanocomposite Scaffolds: A Comparative Study Between Human Mesenchymal Stem Cells Derived From Bone, Umbilical Cord Wharton's Jelly, and Adipose Tissue, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2018)
8. Mesoporous Bioactive Glasses: Promising Platforms for Antibacterial Strategies, Acta Biomaterialia (2018)
Experts (# of related papers)
View all Related Experts
Mahmoud Azami (5)
Nasrin Lotfibakhshaiesh (4)
Other Related Docs
9. Bioactive Glasses Entering the Mainstream, Drug Discovery Today (2018)
10. Mesoporous Bioactive Glasses (Mbgs) in Cancer Therapy: Full of Hope and Promise, Materials Letters (2019)
11. A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold With Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies, Journal of the European Ceramic Society (2021)
12. Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine, Journal of Functional Biomaterials (2022)
13. Endothelial and Osteoblast Differentiation of Adipose-Derived Mesenchymal Stem Cells Using a Cobalt-Doped Cap/Silk Fibroin Scaffold, ACS Biomaterials Science and Engineering (2019)
14. Fabrication of Bioactive Glass Coating on Pure Titanium by Sol-Dip Method: Dental Applications, Dental Materials Journal (2021)
15. Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering, Materials (2017)
16. Biological Evaluation of Porous Nanocomposite Scaffolds Based on Strontium Substituted Β-Tcp and Bioactive Glass: An in Vitro and in Vivo Study, Materials Science and Engineering C (2019)
17. When Size Matters: Biological Response to Strontium- and Cobalt-Substituted Bioactive Glass Particles, Materials Today: Proceedings (2018)
18. Synthesis and Physico-Chemical Characterization of Fluoride (F)- a Nd Silver (Ag)-Substituted Sol-Gel Mesoporous Bioactive Glasses, Biomedical Glasses (2019)
19. Synthesis, Characterization and Biological Evaluation of a New Sol-Gel Derived B and Zn-Containing Bioactive Glass: In Vitro Study, Silicon (2018)
20. Synthesis, Characterization and in Vitro Biological Evaluation of Sol-Gel Derived Sr-Containing Nano Bioactive Glass, Silicon (2017)
21. Bioactive Glasses and Calcium Phosphates, Biomaterials for Oral and Dental Tissue Engineering (2017)
22. Preparation and Characterization of 58S Bioactive Glass Based Scaffold With Kaempferol-Containing Zein Coating for Bone Tissue Engineering, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2021)
23. Investigation of Osteoinductive Effects of Different Compositions of Bioactive Glass Nanoparticles for Bone Tissue Engineering, ASAIO Journal (2017)
24. Functionalization and Surface Modifications of Bioactive Glasses (Bgs): Tailoring of the Biological Response Working on the Outermost Surface Layer, Materials (2019)
25. Ultra-Fast, Highly Efficient and Green Synthesis of Bioactive Forsterite Nanopowder Via Microwave Irradiation, Materials Science and Engineering C (2018)
26. On the Bioactivity and Mechanical Properties of Gehlenite Nanobioceramic: A Comparative Study, Journal of Medical Signals and Sensors (2020)
27. Using Bioactive Glasses in the Management of Burns, Frontiers in Bioengineering and Biotechnology (2019)
28. Acceleration of Bone Regeneration in Bioactive Glass/Gelatin Composite Scaffolds Seeded With Bone Marrow-Derived Mesenchymal Stem Cells Over-Expressing Bone Morphogenetic Protein-7, Materials Science and Engineering C (2017)
29. Effect of Addition of Titanium on Structural, Mechanical and Biological Properties of 45S5 Glass-Ceramic, Ceramics International (2018)
30. Bone Regeneration in Rat Using a Gelatin/Bioactive Glass Nanocomposite Scaffold Along With Endothelial Cells (Huvecs), International Journal of Applied Ceramic Technology (2018)
31. Synthesis, Characterization and in Vitro Bioactivity of Mesoporous Copper Silicate Bioactive Glasses, Ceramics International (2018)
32. Selective Contribution of Bioactive Glasses to Molecular and Cellular Pathways, ACS Biomaterials Science and Engineering (2020)
33. Synergistic Combination of Bioactive Glasses and Polymers for Enhanced Bone Tissue Regeneration, Materials Today: Proceedings (2018)
34. Preparation of a Biomimetic Composite Scaffold From Gelatin/Collagen and Bioactive Glass Fibers for Bone Tissue Engineering, Materials Science and Engineering C (2016)
35. Synthesis, Characterization, and in Vitro Biological Evaluation of Copper-Containing Magnetic Bioactive Glasses for Hyperthermia in Bone Defect Treatment, ACS Biomaterials Science and Engineering (2018)