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Effect of Addition of Titanium on Structural, Mechanical and Biological Properties of 45S5 Glass-Ceramic Publisher



Heidari S1 ; Hooshmand T1 ; Yekta BE2 ; Tarlani A3 ; Noshiri N4 ; Tahriri M5
Authors
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Authors Affiliations
  1. 1. Department of Dental Biomaterials, School of Dentistry/Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Ceramic Division, School of Metallurgy and Materials Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
  3. 3. Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Tehran-Karaj, Iran
  4. 4. Medical Image Processing laboratory (MIPL), Alzahra University, Tehran, Iran
  5. 5. School of Dentistry, Marquette University, Milwaukee, WI, United States

Source: Ceramics International Published:2018


Abstract

The purpose of the present study was to evaluate the effect of addition of titanium on the structural, mechanical, and biological properties of sol-gel derived 45S5 bioactive glass-ceramic. For the synthesis of 45S5 glass ceramics, 5 and 10 mol% titanium were added to replace calcium named as Ti5 and Ti10, respectively. The structure of glass-ceramic was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), and energy dispersive X-ray spectroscopy (EDS). The ability of glass-ceramics to form hydroxyapatite (HA) was also evaluated using XRD, FTIR and FE-SEM/EDS following immersion in the simulated body fluid (SBF) for 1, 7 and 14 days. The ion release potential was also evaluated during the afore-mentioned immersion periods. Furthermore, the cell viability and alkaline phosphatase (ALP) activity of osteoblast-like cells exposed to the dissolved products of glass-ceramics were evaluated. The effect of addition of titanium on the mechanical properties was evaluated by measuring the compressive strength. Despite the slower rate of HA formation in Ti-containing groups during the first day of immersion, all groups showed similar results after 14 days. The addition of titanium to 45S5 bioactive glass-ceramic decreased the silicon and sodium ion release. Ti5 showed the highest level of cell viability and ALP activity. The compressive strength of 45S5 glass-ceramic significantly increased following addition of titanium, and Ti10 showed the highest value. In conclusion, the findings of this study support the synthesis of 45S5 glass-ceramic modified by addition of 5 mol% titanium ions due to improved mechanical and biological properties along with the ability to control solubility and ion release profile. © 2018 Elsevier Ltd and Techna Group S.r.l.
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