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Prevalence of Osteoporosis and Vitamin D Receptor Gene Polymorphisms (Foki) in an Iranian General Population Based Study (Kurdistan) (Imos)



Mohammadi Z1 ; Keshtkar A1 ; Fayyazbakhsh F2 ; Ebrahimi M1 ; Amoli MM3 ; Ghorbani M4 ; Khashayar P1 ; Dini M5 ; Ebrahimirad M6 ; Larijani B3
Authors
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Authors Affiliations
  1. 1. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Biomedical Engineering Department, Maziar University, Rouyan, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Non-communicable Disease Department, Iran Ministry of Health and Medical Education, Tehran, Iran
  6. 6. Biochemistry Department, Pasteur Institute of Iran, Tehran, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2015

Abstract

Background: Osteoporosis, or porous bone, is a disease characterized by low bone mass density (BMD) and structural deterioration of bone tissue, leading to bone fragility and increased risk of hip, spine, and wrist fractures. There are numerous risk factors for osteoporosis. While many of these factors are non-genetic in nature, there is a definite genetic component responsible for this condition. The main aim of this study was to evaluate the association between VDR (Vitamin D receptor gene) polymorphisms (Fok1) A > G (rs2228570) and bone mineral density in an Iranian defined population. Methods: The study participants comprised of 1032 Iranians recruited from the city of Sanandaj during IMOS (Iranian Multi Center Osteoporosis Study). Bone mineral density measurement was performed in all the participants with and without osteoporosis. All samples were genotyped for VDR genes (Fok1) polymorphism with polymerase chain reaction, using a predesigned TaqMan allele discrimination assay. Results: There was a significant association between Fok1 polymorphism and osteoporosis in postmenopausal women, 0.138 (0.025-0.768). Conclusion: It seems that cohort studies, which are more powerful than case-control studies, can be useful in evaluating the roles of genetic variants as risk or protective factors for osteoporosis.
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