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Risk and Predictors of In-Hospital Mortality From Covid-19 in Patients With Diabetes and Cardiovascular Disease Publisher



Rastad H1 ; Karim H2 ; Ejtahed HS3, 4 ; Tajbakhsh R5 ; Noorisepehr M6 ; Babaei M5 ; Azimzadeh M7 ; Soleimani A5 ; Inanloo SH5 ; Shafiabadi Hassani N5 ; Rasanezhad F5 ; Shahrestanaki E5 ; Khodaparast Z1 ; Golami H5 Show All Authors
Authors
  1. Rastad H1
  2. Karim H2
  3. Ejtahed HS3, 4
  4. Tajbakhsh R5
  5. Noorisepehr M6
  6. Babaei M5
  7. Azimzadeh M7
  8. Soleimani A5
  9. Inanloo SH5
  10. Shafiabadi Hassani N5
  11. Rasanezhad F5
  12. Shahrestanaki E5
  13. Khodaparast Z1
  14. Golami H5
  15. Qorbani M5, 8
Show Affiliations
Authors Affiliations
  1. 1. Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Research Center for Health, Safety and Environment (RCHSE), Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Diabetology and Metabolic Syndrome Published:2020


Abstract

Background: Diabetes mellitus (DM) and cardiovascular disease (CVD) are present in a large number of patients with novel Coronavirus disease 2019 (COVID-19). We aimed to determine the risk and predictors of in-hospital mortality from COVID-19 in patients with DM and CVD. Methods: This retrospective cohort study included hospitalized patients aged ≥ 18 years with confirmed COVID-19 in Alborz province, Iran, from 20 February 2020 to 25 March 2020. Data on demographic, clinical and outcome (in-hospital mortality) data were obtained from electronic medical records. Self-reported comorbidities were classified into the following groups: DM(having DM with or without other comorbidities), only DM(having DM without other comorbidities), CVD(having CVD with or without other comorbidities), only CVD(having CVD without other comorbidities), and having any comorbidity. Multivariate logistic regression models were fitted to quantify the risk and predictors of in-hospital mortality from COVID-19 in patients with these comorbidities. Results: Among 2957 patients with COVID-19, 2656 were discharged as cured, and 301 died. In multivariate model, DM (OR: 1.62 (95% CI 1.14-2.30)) and only DM (1.69 (1.05-2.74)) increased the risk of death from COVID-19; but, both CVD and only CVD showed non-significant associations (p > 0.05). Moreover, having any comorbiditiesincreased the risk of in-hospital mortality from COVID-19 (OR: 2.66 (95% CI 2.09-3.40)). Significant predictors of mortality from COVID-19 in patients with DM were lymphocyte count, creatinine and C-reactive protein (CRP) level (all P-values < 0.05). Conclusions: Our findings suggest that diabetic patients have an increased risk of in-hospital mortality following COVID-19; also, lymphocyte count, creatinine and CRP concentrations could be considered as significant predictors for the death of COVID-19 in these patients. © 2020 The Author(s).
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