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Therapeutic Potentials and Candidates for Covid-19 Publisher



Rezghi Rami M1 ; Meskini M2, 3, 4 ; Rezaei Khozani N5 ; Forouzandehdel S6 ; Momtaz S7, 8, 9 ; Ghosh S10 ; Rezaei N4, 11, 12 ; Abdolghaffari AH9, 13
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  2. 2. Mycobacteriology & Pulmonary Research Department, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Department of Microbiology, Faculty of Medicine, Kashan University of Medical Science, Kashan, Iran
  6. 6. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  7. 7. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran
  8. 8. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), and Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  10. 10. Department of Genetics, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, 9301, South Africa
  11. 11. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Dr Qarib St., Keshavarz Blvd, P.O. Box: 14194, Tehran, Iran
  12. 12. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, No. 99, Yakhchal, Gholhak, Shariati St, P.O. Box: 19419-33111, Tehran, Iran

Source: Iranian Journal of Science Published:2023


Abstract

The current coronavirus disease 2019 (COVID-19) outbreak spread rapidly worldwide. Yet, there is no identifiable antiviral treatment, so an effective drug is urgently needed. Preventive strategies and oxygen therapy are the main practical approaches to prevent and treat COVID-19. Clinical trials are in progress for the antiviral and immunomodulation agents that eventually are being developed for COVID-19 treatment. Pharmacological, immunotherapies, natural-based supplements, biologics, and combination therapies interventions have been established. The concept of drug repurposing was re-visited, and many conventional antivirals or immunosuppresses were evaluated for Efficacy against COVID-19 infection. Even though much has been published, the rapid progression of therapeutic strategies and unpredictable disease alterations necessitates continual information updates. This review defines drug repurposing and summarizes a medication developed for other therapeutic approaches rather than SARS-CoV-2 treatment. Furthermore, we provide data on the effectiveness of traditional Chinese medicines (TCM) on COVID-19. Additionally, biological and advanced Nano-based drug delivery systems are reviewed. © 2023, The Author(s), under exclusive licence to Shiraz University.
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