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Conventional Mri-Derived Subchondral Trabecular Biomarkers and Their Association With Knee Cartilage Volume Loss As Early As 1 Year: A Longitudinal Analysis From Osteoarthritis Initiative Publisher Pubmed



Pishgar F1 ; Ashrafganjouei A2 ; Dolatshahi M3 ; Guermazi A4 ; Zikria B5 ; Cao X5 ; Wan M5 ; Roemer FW4, 6 ; Dam E7 ; Demehri S1
Authors
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Authors Affiliations
  1. 1. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 4240, Baltimore, 21287, MD, United States
  2. 2. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Science Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, MA, United States
  5. 5. Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  6. 6. Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany
  7. 7. Machine Learning Section, Department of Computer Science, University of Copenhagen, Kobenhavns, Denmark

Source: Skeletal Radiology Published:2022


Abstract

Objective: To study associations between MRI-derived subchondral trabecular biomarkers obtained from conventional MRI sequences and knee cartilage loss over 12 and 24 months, using the FNIH osteoarthritis (OA) biomarkers consortium. Materials and methods: Data of the 600 subjects in the FNIH OA biomarkers consortium (a nested case–control study within Osteoarthritis Initiative [OAI]) were extracted from the online database. Baseline knee MRI (intermediate-weighted (IW) sequences) were evaluated to determine conventional MRI-derived trabecular thickness (cTbTh) and bone-to-total ratio (cBV/TV). The measurements for medial and lateral volumes of cartilages using baseline, 12-, and 24-month knee MRI were extracted from the OAI database, and cartilage volume loss over 12 and 24 months of follow-up were determined using Relative Change Index. The association between conventional MRI-based subchondral trabecular biomarkers and cartilage volume loss were studied using logistic regression models, adjusted for relevant confounders including age, sex, body mass index (BMI), vitamin D use, Kellgren Lawrence grade (KLG), and tibiofemoral alignment. Results: Higher medial cTbTh and cBV/TV at baseline were associated with increased odds of medial tibial cartilage volume loss over 12 months (ORs: 1.01 [1.00–1.02] and 1.24 [1.10–1.39] per 1-SD change) and 24 months (ORs: 1.01 [1.00–1.02] and 1.22 [1.08–1.37], per 1-SD change). No significant association was observed between medial subchondral trabecular biomarkers and lateral tibial or femoral (medial or lateral) cartilage volume loss over the first and second follow-up years. Conclusions: Conventional MRI-derived subchondral trabecular biomarkers (higher medial cTbTh and cBV/TV) may be associated with increased medial tibial cartilage volume loss as early as 1 year. © 2022, The Author(s), under exclusive licence to International Skeletal Society (ISS).
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