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Thigh Muscle Composition Changes in Knee Osteoarthritis Patients During Weight Loss: Sex-Specific Analysis Using Data From Osteoarthritis Initiative Publisher Pubmed



Moradi K1 ; Mohajer B1 ; Mohammadi S2 ; Guermazi A3 ; Ibad HA1 ; Roemer FW3, 4 ; Cao X5 ; Link TM6 ; Demehri S1
Authors
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Authors Affiliations
  1. 1. Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Radiology, Chobanian & Avedisian Boston University School of Medicine, Boston, MA, United States
  4. 4. Department of Radiology, Universitatsklinikum Erlangen & Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany
  5. 5. Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States
  6. 6. Department of Radiology and Biomedical Imaging, University of California, San Francisco, 94158, CA, United States

Source: Osteoarthritis and Cartilage Published:2024


Abstract

Objectives: Sex of patients with knee osteoarthritis (KOA) may impact changes in thigh muscle composition during weight loss, the most well-known disease-modifying intervention. We investigated longitudinal sex-based changes in thigh muscle quality during weight loss in participants with KOA. Methods: Using Osteoarthritis Initiative (OAI) cohort data, we included females and males with baseline radiographic KOA who experienced > 5 % reduction in Body Mass Index (BMI) over four years. Using a previously validated deep-learning algorithm, we measured Magnetic Resonance Imaging (MRI)-derived biomarkers of thigh muscles at baseline and year-4. Outcomes were the intra- and inter-muscular adipose tissue (Intra-MAT and Inter-MAT) and contractile percentage of thigh muscles between females and males. The analysis adjusted for potential confounders, such as demographics, risk factors, BMI change, physical activity, diet, and KOA status. Results: A retrospective selection of available thigh MRIs from KOA participants who also had a 4-year weight loss (>5 % of BMI) yielded a sample comprising 313 thighs (192 females and 121 males). Female and male participants exhibited a comparable degree of weight loss (females: −9.72 ± 4.38, males: −8.83 ± 3.64, P-value=0.060). However, the changes in thigh muscle quality were less beneficial for females compared to males, as shown by a less degree of longitudinal decrease in Intra-MAT (change difference,95 %CI: 783.44 mm2/4-year, 505.70 to 1061.19, P-value<0.001) and longitudinal increase in contractile percentage (change difference,95 %CI: −3.9 %/4-year, −6.5 to −1.4, P-value=0.019). Conclusions: In participants with KOA and 4-year weight loss, the longitudinal changes in thigh muscle quality were overall beneficial but to a less degree in females compared to males. Further research is warranted to investigate the underlying mechanisms and develop sex-specific interventions to optimize muscle quality during weight loss. © 2024
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