Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure Publisher Pubmed



Mahmoudi MJ1 ; Hedayat M2 ; Taghvaei M3 ; Harsini S4, 10 ; Nematipour E5 ; Farhadi E6 ; Mahmoudi M7 ; Sadr M3 ; Esfahanian N3 ; Nourijelyani K8 ; Amirzargar AA3, 9 ; Rezaei N3, 4, 9, 10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Division of Cardiology, Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States
  3. 3. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Hematology Department, School of Allied Medical Science, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Acta Biomedica Published:2019


Abstract

Background: As cytokines, including interleukin-10 (IL-10) and transforming growth factor beta 1(TGF-Β1) seem to contribute towards the pathogenesis of chronic heart failure (CHF), this study was performed to assess the associations of certain single nucleotide polymorphisms (SNPs) of these genes in a case control study. Methods: This investigation was carried out to determine the frequency of alleles, genotypes and haplotypes of TGF-Β1 and IL-10 single-nucleotide polymorphisms (SNPs) in 57 Iranian patients with CHF compared with 140 healthy subjects using polymerase chain reaction with sequence-specific primers method. Results: Results of the analyzed data divulged a negative association for both TGF-Β1 GC genotype at codon 25 (P=0.047) and CT genotype at codon 10 (P=0.018) and CHF proneness. Although, TGF-Β1 CC genotype at codon 10 was found to be positively associated with CHF (P=0.011). Moreover, the frequency of IL-10 (-1082,-819,-592) ATA haplotype and TGF-Β1 (codon 10, codon 25) TG haplotype were significantly lower in the patients group (P=0.004 and P=0.040, respectively), while TGF-Β1 (codon 10, codon 25) CG haplotype was overrepresented in patients with CHF (P=0.007). Conclusions: Cytokine gene polymorphisms might affect vulnerability to CHF. Particular genotypes and haplotypes in IL-10 and TGF-Β1 genes could render individuals more susceptible to CHF. © Mattioli 1885.
Related Docs
View other Related Docs
1. Interleukin-2 and Interferon-Gamma Single Nucleotide Polymorphisms in Iranian Patients With Chronic Heart Failure, Avicenna Journal of Medical Biotechnology (2018)
2. Association of Interleukin 1 Gene Cluster and Interleukin 1 Receptor Gene Polymorphisms With Ischemic Heart Failure, Bratislava Medical Journal (2016)
3. Lack of Association Between Interleukin-10, Transforming Growth Factor-Beta Gene Polymorphisms and Juvenile-Onset Systemic Lupus Erythematosus, Clinical Rheumatology (2015)
4. Association of Interleukin-2 and Interferon-Γ Single Nucleotide Polymorphisms With Juvenile Systemic Lupus Erythematosus, Allergologia et Immunopathologia (2016)
5. Interleukin 10 and Transforming Growth Factor Beta 1 Gene Polymorphisms in Juvenile Idiopathic Arthritis, Bratislava Medical Journal (2016)
6. Tumor Necrosis Factor-Alpha Single Nucleotide Polymorphisms in Juvenile Systemic Lupus Erythematosus, Human Immunology (2015)
7. Tumor Necrosis Factor-Alpha and Interleukin-6 Gene Polymorphisms in Iranian Patients With Ischemic Heart Failure, Avicenna Journal of Medical Biotechnology (2018)
8. Association of Tumour Necrosis Factor-Alpha G/A -238 and G/A -308 Single Nucleotide Polymorphisms With Juvenile Idiopathic Arthritis, International Journal of Immunogenetics (2016)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (34)
Vahid Ziaee (18)
Other Related Docs
9. Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms in Autoimmune Hepatitis, Annals of Hepatology (2018)
10. Significance of Il-1Ra Polymorphism in Iranian Patients With Inflammatory Bowel Disease, Digestive Diseases and Sciences (2015)
11. Association of Interleukin-6 Single Nucleotide Polymorphisms With Juvenile Idiopathic Arthritis, Clinical Rheumatology (2017)
12. Association of Interleukin-1 Gene Cluster and Interleukin-1 Receptor Polymorphisms With Febrile Seizures, Journal of Child Neurology (2016)
13. Association of Interleukin-1 Family Gene Polymorphisms With Juvenile Idiopathic Arthritis in Iranian Population, Allergologia et Immunopathologia (2016)
14. Polymorphisms of Genes Encoding Interleukin-4 and Its Receptor in Iranian Patients With Juvenile Idiopathic Arthritis, Clinical Rheumatology (2016)
15. Single Nucleotide Polymorphisms of Tnf-A Gene in Febrile Seizures, Journal of the Neurological Sciences (2015)
16. Autoimmune Diseases, Clinical Immunology (2022)
17. Interleukin-4 Cytokine Single Nucleotide Polymorphisms in Kawasaki Disease: A Case-Control Study and a Review of Knowledge, International Journal of Rheumatic Diseases (2018)
18. Association of Interleukin-2, But Not Interferon-Gamma, Single Nucleotide Polymorphisms With Juvenile Idiopathic Arthritis, Allergologia et Immunopathologia (2016)
19. Pdcd1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis, Acta Medica Iranica (2017)
20. Interleukin-23 Receptor Gene Polymorphisms in Iranian Patients With Juvenile Systemic Lupus Erythematosus, Allergologia et Immunopathologia (2020)
21. Ptpn22 Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus, Fetal and Pediatric Pathology (2020)
22. Il-6 174 G/C Polymorphism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis, Acta Medica Iranica (2018)
23. Interleukin 10 and Transforming Growth Factor Beta Polymorphisms As Risk Factors for Kawasaki Disease: A Case-Control Study and Meta-Analysis, Avicenna Journal of Medical Biotechnology (2019)
24. Pdcd1 Single Nucleotide Genes Polymorphisms Confer Susceptibility to Juvenile-Onset Systemic Lupus Erythematosus, Autoimmunity (2015)
25. Association Study of Mecp2 Gene Single Nucleotide Polymorphisms in Juvenile-Onset Systemic Lupus Erythematosus Patients From Iran, Fetal and Pediatric Pathology (2017)
26. Pro-Inflammatory Cytokine Single Nucleotide Polymorphisms in Kawasaki Disease, International Journal of Rheumatic Diseases (2018)
27. Association Study of Interleukin-1 Family and Interleukin-6 Gene Single Nucleotide Polymorphisms in Recurrent Aphthous Stomatitis, International Journal of Immunogenetics (2015)
28. Association of Stat4 Gene Single Nucleotide Polymorphisms With Iranian Juvenile-Onset Systemic Lupus Erythematosus Patients, Turkish Journal of Pediatrics (2017)
29. Single Nucleotide Polymorphisms of Il-2, But Not Il-12 and Ifn-Γ, Are Associated With Increased Susceptibility to Chronic Spontaneous Urticaria, Allergologia et Immunopathologia (2017)
30. Association of Il4 Single-Nucleotide Polymorphisms With Febrile Seizures, Journal of Child Neurology (2015)
31. Association of Tgfb, But Not Il10, Single Nucleotide Polymorphisms With Febrile Seizures, Seizure (2015)
32. Il4 Gene Polymorphisms in Iranian Patients With Autoimmune Hepatitis, Expert Review of Gastroenterology and Hepatology (2016)
33. The Role of Interleukin 4 and Il-4Ra in Intervertebral Disc Degeneration: Investigation of Single Nucleotide Polymorphisms in Genes and a Systematic Review & Meta-Analysis of Il-4 Expression Level, British Journal of Neurosurgery (2020)
34. Association of Il10 and Tgfb Single Nucleotide Polymorphisms With Intervertebral Disc Degeneration in Iranian Population: A Case Control Study, BMC Medical Genetics (2018)