Effect of Saffron (Crocus Sativus L.), As a Bioenhancer, on Pharmacokinetic of Acetaminophen: An Animal Study Publisher



Lamardi SNS^{1, 2} ; Ardekani MRS^{2, 3} ; Mireskandari K⁴ ; Sharifzadeh M⁵ ; Yakhchali M⁶ ; Sadrai S⁴ Show Affiliations
Source: Traditional and Integrative Medicine Published:2023

Abstract

In Traditional Persian Medicine (TPM) saffron is used as an accompaniment agent “Mobadreq” in polyherbal formulations. According to TPM texts, “Mobadreq” is a substance (or drug) which facilitates access of drugs or food to the whole body or specific organs. This study investigated the effect of oral co-administration of Crocus sativus L. (saffron) on the absorption and some pharmacokinetic parameters of acetaminophen in rats. Two groups of rats (n=6) were treated by 1: acetaminophen 10 mg/kg along with Crocus sativus 4 mg/kg (test group) and 2: 10 mg/kg acetaminophen (control). The plasma concentrations of acetaminophen after oral administration (at 0, 5, 10, 15, 20, 40, 60, 90, and 120 min) were monitored by an HPLC-UV method. Results indicated that the plasma concentration of acetaminophen in the test group was reached to the maximum concentration (Cmax) faster than control group. As a result, at 5 to 40 minutes after drug gavage, the concentration of acetaminophen in both groups was significantly different. It was also found that co-administration of acetaminophen and saffron significantly increased acetaminophen’s area under concentration curve (AUC0-60) in comparison to the acetaminophen alone (p<0.025). These results suggest that saffron could increase the absorption rate of acetaminophen. Consequently, saffron can be considered and introduced as an enhancer of absorption rate and efficacy of acetaminophen and other drugs at least by oral route and the drug interactions with this herb should be considered. © 2023 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license.