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Application of Saffron As a Neuroprotective Agent Publisher



Akhondzadeh S1 ; Mortazavi SH1 ; Sahebolzamani E1 ; Mortezaei A1
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Authors Affiliations
  1. 1. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Saffron: Science# Technology and Health Published:2020


Abstract

Alzheimer’s disease (AD) is the most common form of dementia and causes neuron death, which leads to memory loss and cognitive dysfunction. The aggregation of Aβ and the impairment of tau protein are the most famous mechanisms to explain the pathogenesis of AD. Pharmacological therapies with acetylcholineesterase inhibitors and N-methyl d-aspartate glutamate receptor blockers are used to treat AD. Saffron (Crocus sativus) is a medicinal plant and has been used to in traditional medicine for centuries to treat diseases. This chapter covers the prominent findings on the pharmacological/therapeutic properties of saffron on the central nervous system, specifically its application in the treatment of AD. © 2020 Elsevier Inc. All rights reserved.
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