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Effect of Vitamin a Supplementation on Fatigue and Depression in Multiple Sclerosis Patients: A Double-Blind Placebo-Controlled Clinical Trial Pubmed



Bitarafan S1 ; Sabooryaraghi A2 ; Sahraian MA3 ; Soltani D1 ; Nafissi S1 ; Togha M3 ; Moghadam NB4 ; Roostaei T1 ; Honarvar NM2 ; Harirchian MH1
Authors
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Authors Affiliations
  1. 1. Department of Neurology, Iranian Center of Neurological Research, Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, 1419733141, Iran
  2. 2. Department of Molecular and Cellular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neurology, Sina MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Allergy# Asthma and Immunology Published:2016


Abstract

Decreasing the population and activation of inflammatory T helper cells in multiple sclerosis (MS) patients using vitamin A derivatives (retinoic acids) has been well documented. The present study determined the effect of vitamin A supplementation on psychiatric signs in MS patients. The subjects were 101 relapsing-remitting MS patients enrolled in a placebo-controlled randomized clinical trial. The treatment group was administered 25000 IU/d retinyl palmitate (RP) for 6 months followed by 10000 IU/d RP for another 6 months. The results for baseline characteristics, modified fatigue impact scale and Beck Depression Inventory-II were recorded at the beginning and end of the one-year study. The non-normal distribution data was compared between groups using a nonparametric test and normal distribution data was analyzed using a parametric test. (ClinicalTrials.gov Identifiers: NCT01417273). The results showed significant improvement in the treatment group for fatigue (p=0.004) and depression (p=0.01). Vitamin A supplementation helped during interferon therapy in the treatment process and improved psychiatric outcomes for anti-inflammatory mechanisms. © Copyright Winter 2016, Iran J Allergy Asthma Immunol. All rights reserved.
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