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Effect of Ginseng on Fatigue Related to Neuromyelitis Optica Spectrum Disorder: A Double-Blinded Randomized Controlled Clinical Trial Publisher



Aslzadeh S1 ; Shahmirzaei S1 ; Sahraian MA2 ; Mozdabadi RSK2 ; Aliabadi HR3 ; Gheini MR1 ; Rezaeimanesh N2 ; Eskandarieh S1 ; Majidi F4 ; Moghadasi AN2
Authors
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Authors Affiliations
  1. 1. Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Bam University of Medical Sciences, Bam, Iran
  4. 4. Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Caspian Journal of Internal Medicine Published:2024


Abstract

Background: The effects of ginseng on fatigue have been proven in patients with multiple sclerosis (MS), which have several similar manifestations to neuromyelitis optica spectrum disorder (NMOSD) patients. This study was designed to evaluate the effects of ginseng on fatigue in NMOSD patients. Methods: In this double-blinded randomized controlled clinical trial, 64 patients were recruited and were allocated into two study groups (ginseng or placebo) via block randomization. The participants received either 250-mg ginseng or placebo twice daily for a 3-month period. Also, the measurement of outcome was performed using the valid and reliable Persian version of fatigue severity scale (FSS) questionnaire, which was filled by patients once after enrollment in the study and once at the end of the study post-intervention. Results: In total, 58 patients finished the study with no major side effects. There were no significant differences in demographic, clinical, as well as FSS between two study groups (p>0.05). Ginseng supplementation significantly reduced fatigue (40.21±13.51 vs. 28.97±14.18; p<0.01), while patients in the placebo group showed significantly higher fatigue score after 3 months post-intervention (35.03±13.51 vs. 38.79±12.27; P: 0.02). The extent of changes in the fatigue score in the ginseng group was significantly greater than in the placebo group (p <0.01). Conclusion: This study revealed positive effects of ginseng on reducing fatigue in NMOSD patients with no major side effects. In this regard, further studies are warranted to evaluate and clarify the effects of ginseng on fatigue in NMOSD. © 2024 Babol University of Medical Sciences. All rights reserved.
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