Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Systematic Review and Meta-Analysis on the Diagnostic and Prognostic Values of 18F-Fdg Pet in Uveal Melanoma and Its Hepatic Metastasis Publisher



Mirshahvalad SA1, 2 ; Zamanisiahkali N1, 3 ; Pirich C1 ; Beheshti M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Division of Molecular Imaging and Theranostics, Department of Nuclear Medicine, University Hospital, Paracelsus Medical University, Salzburg, 5020, Austria
  2. 2. Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital & Women’s College Hospital, University Medical Imaging Toronto (UMIT), University of Toronto, Toronto, M5G 2N2, ON, Canada
  3. 3. Research Centre for Nuclear Medicine, Department of Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, 1461884513, Iran

Source: Cancers Published:2024


Abstract

In this systematic review and meta-analysis (PRISMA-compliant), we tried to investigate diagnostic and prognostic values of 18F-FDG PET in uveal melanoma. A systematic search was conducted on the main medical literature databases to include studies that evaluated 18F-FDG PET as the imaging modality to evaluate patients with uveal melanoma. Overall, 27 studies were included. Twelve had data about the detection rate of 18F-FDG PET in primary intra-ocular tumours. The pooled sensitivity was 45% (95%CI: 41–50%). Furthermore, studies showed that the larger the primary tumour, the higher its uptake. Among the included studies, 13 assessed 18F-FDG PET in detecting metastasis. The pooled sensitivity and specificity were 96% (95%CI: 81–99%) and 100% (95%CI: 94–100%), respectively. Regarding liver metastasis, they were 95% (95%CI: 79–99%) and 100% (95%CI: 91–100%), respectively. Noteworthy, the level of 18F-FDG uptake was a strong predictor of patient survival. Lastly, 18F-FDG PET could characterise lesions from the histopathology perspective, distinguishing high-risk from low-risk diseases. Overall, although not reliable in detecting primary intra-ocular tumours, 18F-FDG PET is highly accurate for diagnosing metastatic uveal melanomas. It can also be a highly valuable modality in terms of patient prognostication. Thus, 18F-FDG PET can be recommended in patients diagnosed with uveal melanoma to enhance decision-making and patient management. © 2024 by the authors.
Related Docs
1. Non-Cutaneous Melanoma, Findings and Prognostic Value of Fdg Pet/Ct: A Case Series of 23 Patients and Review of the Literature, Asia Oceania Journal of Nuclear Medicine and Biology (2022)
2. Diagnostic Performance of [18F]F-Fdg Positron Emission Tomography (Pet) in Non-Ophthalmic Malignant Melanoma: A Systematic Review and Meta-Analysis of More Than 10,000 Melanoma Patients, Cancers (2024)
Experts (# of related papers)
View all Related Experts
Alireza Emami Ardakani (1)
Armaghan Fard Esfahani (1)