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Voltammetric Determination of Dopamine in the Presence of Tyrosine Using Graphite Screen-Printed Electrode Modified With Graphene Quantum Dots Publisher



Beitollahi H1 ; Dourandish Z2 ; Ganjali MR3, 4 ; Shakeri S5
Authors
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Authors Affiliations
  1. 1. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
  2. 2. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran
  3. 3. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran
  4. 4. Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

Source: Ionics Published:2018


Abstract

Dopamine (DA) is an important neurotransmitter that belongs to the catecholamine group and plays a very significant role in the central nervous, renal, hormonal, and cardiovascular systems. As a result, dysfunction of the dopaminergic system in the central nervous system (CNS) has been related to neurological disorders such as schizophrenia and Parkinson’s disease. Therefore, in this work, a screen-printed electrode was modified by graphene quantum dots (GQD/SPE) in order to be used as sensor for dopamine in the presence of tyrosine. To evaluate the efficiency of the developed electrode toward detection of dopamine and tyrosine in aqueous solutions, various electrochemical methods including cyclic voltammetry (CV), chronoamperometry (CHA), and differential pulse voltammetry (DPV) techniques were employed. Application of GQD/SPE created a separation of 435 mV in the oxidation peak potentials of dopamine and tyrosine. The calibration curves were within the range of 0.1–1000.0 and 1.0–900.0 μM for dopamine and tyrosine, respectively. The detection limits (S/N = 3) were determined as 0.05 and 0.5 μM for dopamine and tyrosine, respectively. The diffusion coefficients using chronoamperometry at the surface of modified electrode were determined as 9.0 × 10−5 and 6.4 × 10−5 cm2 s−1 for dopamine and tyrosine, respectively. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
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