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Simultaneous Voltammetric Determination of Droxidopa, Acetaminophen, and Tyrosine on Hematoxylin and Graphene Oxide/Zno Nanocomposite-Modified Glassy Carbon Electrode Publisher



Beitollahi H1 ; Salimi H2 ; Ganjali MR3, 4
Authors
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Authors Affiliations
  1. 1. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
  2. 2. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran
  3. 3. Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran
  4. 4. Biosensor Research Center, Endocrinology and Metabolism Molecular–Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Ionics Published:2018


Abstract

Hematoxylin was used in combination with graphene oxide/ZnO nanocomposites as the adhesives for fabricating sensitivity-enhanced electrochemical droxidopa sensor. The electrochemical method showed an excellent character for electrocatalytic oxidization of droxidopa in the presence of acetaminophen and tyrosine. In addition, the experimental parameters such as pH values and the scan rate were optimized. Due to the fine characteristics of modified electrode, a good linear relationship between the anodic peak current and droxidopa concentration in the range 0.075–800.0 μM was observed. The detection limit (3σ) obtained by square wave voltammetry was 4.5 × 10−8 M (S/N = 3). This modified electrode showed excellent selectivity for the determination of droxidopa in the presence of acetaminophen and tyrosine. The prepared sensor was used for determination of droxidopa, acetaminophen, and tyrosine in the real samples. © 2017, Springer-Verlag GmbH Germany.
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