Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier

Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier Publisher

Gandomi F¹ ; Marzi Khosrowshahi E² ; Sohouli E³ ; Aghaei M⁴ ; Saleh Mohammadnia M⁵ ; Naghian E⁶ ; Rahiminasrabadi M^{7, 8}

Show Affiliations

1. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
2. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3. Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran
4. Department of Chemical Engineering, School of Chemical and Petroleum Engineering, Shiraz University, Shiraz, Iran
5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6. Department of Chemistry, South Tehran Branch Islamic Azad University, Tehran, 1777613651, Iran
7. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
8. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Journal of Electroanalytical Chemistry Published:2020

Abstract

Linagliptin (LGP) is a novel hypoglycemic drug that belongs to the dipeptidyl-peptidase-4 inhibitor class that was approved in 2011 for the treatment of type 2 diabetes. Today, the integration of different materials and electrochemistry has opened a new horizon to develop highly selective, sensitive, rapid and reliable techniques to detect and quantify such vital analytes. The purpose of this article is to develop an improved carbon paste electrode (CPE) with graphitic carbon nitride/β-cyclodextrin nanocomposite (gCN-βCD/CPE) as an electrochemical sensor for the measurement of LGP. For this purpose, gCN was synthesized from melamine and mixed with βCD to obtain a nanocomposite for the chemical modification of CPE. The influence of modifier on the selectivity, sensitivity, response and lifetime of the CPE was investigated. The results show that the developed LGP electrochemical determination method has a broad range of linearity from 0.01 to 50 μM (R2 > 0.986) based on differential pulse voltammetry (DPV) responses. The detection limit of the method was 3 nM and the probable interference influence on the analytical signal of LGP was insignificant. The improved electrode was successfully used to measure LGP in the blood serum sample with a satisfactory relative recovery (>95.6%). © 2020 Elsevier B.V.

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Style	Citing Format
MLA	Gandomi F, et al.. "Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier." Journal of Electroanalytical Chemistry, vol. 876, no. , 2020, pp. -.
APA	Gandomi F, Marzi Khosrowshahi E, Sohouli E, Aghaei M, Saleh Mohammadnia M, Naghian E, Rahiminasrabadi M (2020). Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier. Journal of Electroanalytical Chemistry, 876(), -.
Chicago	Gandomi F, Marzi Khosrowshahi E, Sohouli E, Aghaei M, Saleh Mohammadnia M, Naghian E, Rahiminasrabadi M. "Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier." Journal of Electroanalytical Chemistry 876, no. (2020): -.
Harvard	Gandomi F et al. (2020) 'Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier', Journal of Electroanalytical Chemistry, 876(), pp. -.
Vancouver	Gandomi F, Marzi Khosrowshahi E, Sohouli E, Aghaei M, Saleh Mohammadnia M, Naghian E, et al.. Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier. Journal of Electroanalytical Chemistry. 2020;876():-.
BibTex	@article{ author = {Gandomi F and Marzi Khosrowshahi E and Sohouli E and Aghaei M and Saleh Mohammadnia M and Naghian E and Rahiminasrabadi M}, title = {Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier}, journal = {Journal of Electroanalytical Chemistry}, volume = {876}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Gandomi F AU - Marzi Khosrowshahi E AU - Sohouli E AU - Aghaei M AU - Saleh Mohammadnia M AU - Naghian E AU - Rahiminasrabadi M TI - Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier JO - Journal of Electroanalytical Chemistry VL - 876 IS - SP - EP - PY - 2020 ER -

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