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Dietary Insulin Index and Load in Relation to Cardiometabolic Risk Factors in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study on the Rancd Cohort Study Publisher Pubmed



Anjomshoae J1 ; Namazi N2 ; Ayati MH3, 4 ; Darbandi M5 ; Najafi F5, 6 ; Pasdar Y5
Authors
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Authors Affiliations
  1. 1. Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
  2. 2. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Cardiovascular Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Nutrition Published:2023


Abstract

Objectives: The aim of the present study was to evaluate the link between the dietary insulin index (DII) and dietary insulin load (DIL) and cardiometabolic risk factors in patients with type 2 diabetes mellitus (T2DM). Method: In this cross-sectional population-based study, 827 participants with diabetes were included based on the RaNCD (Ravansar Non-Communicable Disease) cohort study baseline data. DII and DIL were calculated based on standard formulas using food insulin index values published earlier. Logistic regression analysis was used to determine the association of DII and DIL with cardiovascular risk factors. Results: A significantly direct association was shown between DII and metabolic syndrome (MetS; odds ratio [OR], 1.32; 95% confidence interval [CI], 1.05–2.50). The odds of developing abdominal obesity in patients with the highest DII were almost twice as high as those with the lowest DII (OR, 2.06; 95% CI, 1.02–4.99). Patients in the top quintile of DIL had twice the odds of being obese than those in the bottom quintile. Furthermore, positive associations were found between DIL and both MetS (OR, 1.98; 95% CI, 1.10–4.21) and waist circumference (OR, 2.90; 95% CI, 1.10–7.20). Conclusion: Higher DII and DIL were positively related to greater risks for both MetS and abdominal obesity among patients with T2DM. Additionally, higher DIL was associated with a higher risk for obesity in the Ravansar population. However, further prospective investigations are needed to clarify the cause-and-effect link between DII, DIL, and cardiovascular risk factors in patients with T2DM. © 2022
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