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The Prevalence of Isaba1 and Isaba4 in Acinetobacter Baumannii Species of Different International Clone Lineages Among Patients With Burning in Tehran, Iran Publisher



Bahador A1 ; Raoofian R2 ; Farshadzadeh Z1 ; Beitollahi L1 ; Khaledi A3 ; Rahimi S1 ; Mokhtaran M1 ; Tavana AM4 ; Esmaeili D5
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Genetic, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Microbiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Applied Microbiology Research Center, Department of Microbiology, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Jundishapur Journal of Microbiology Published:2015


Abstract

Background: Multidrug resistant strains of Acinetobacter baumannii (MDR-AB) have emerged as alarming nosocomial pathogens among patients with burning. Objectives: The current study aimed to determine the susceptibility of A. baumannii species, carbapenems resistance patterns, and their association with ISAba1 and ISAba4 elements upstream of the blaOXA-like genes, and the distribution of international clone (IC) of A. baumannii isolates among patients with burning in Tehran, Iran. Materials and Methods: In the current study, 62 A. baumannii species isolates from patients with burning in Tehran, Iran, in 2012 were evaluated for the antimicrobial susceptibility, genetic relationships, ICs, carbapenemase encoding genes, and insertion elements ISAba upstream of blaOXA-like genes. Results: The highest rates of susceptibility were observed with colistin (88.7%) and tigecycline (82.2%). The extensively drug-resistance and pan drug-resistance were observed in 37.1% and 8.1% of the isolates, respectively. About 98.3% of 17 genotypes categorized into three distinct clusters. Thirty-six of the 62 isolates (58%) belonged to the IC II lineage. The most prevalent acquired OXA-type carbapenemase was blaOXA-23-like (62.9%). ISAba1 and ISAba4 were detected upstream of blaOXA-23-like genes in 45.1% and 12.9% of isolates, respectively. In 32.2% of all isolates, ISAba1 laid upstream of blaOXA-51-like genes. The PCR results were negative for carbapenemase genes of Ambler class A and B, except blaVIM-2. (1.6%). Conclusions: It was the first study that attempted to detect the insertion elements ISAba and IC lineages in MDR-AB species isolated from patients with burning in Iran. © 2015, Ahvaz Jundishapur University of Medical Sciences.
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