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Potentiometric Determination of Betahistine in Pharmaceutical Formulations by Drug Selective Sensors



Ganjali MR1, 2 ; Aghili S1 ; Larijani B3 ; Ghasemi MH4
Authors
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran
  2. 2. Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Biosensor Research Center, Tehran, Iran
  3. 3. Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Applied Chemistry Research Group, ACECR-Tehran branch, P.O. Box: 13145-186, Tehran, Iran

Source: International Journal of Electrochemical Science Published:2015

Abstract

Betahistine is histamine like drug that acts as both a partial histamine H1 receptor agonist and as a histamine H3 receptor antagonist. This research introduces design and construction of a PVC membrane sensor and nano-composite carbon paste electrode for fast and simple determination of Betahistine in pharmaceutical formulation. The best electrode performance was obtained with a membrane composition of 30% PVC, 63% NPOE, and 7% ion-pair and paste composition of 53% graphite, 30% paraffin oil, 15% ion-pair and 2% MWCNT. This electrode illustrated fast, stable and Nernstian response over a relatively wide concentration range of 1×10-5 to 1×10-2 mol L-1 for PVC membrane sensor and 1.0×10-6 to 5.0×10-1 mol L-1 for nano-composite carbon paste electrode. Validation of the method shows suitability of the sensors for application in quality control analysis of drug in pharmaceutical formulation. © 2015 The Authors.