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Electrochemical Determination of the Antipsychotic Medication Clozapine by a Carbon Paste Electrode Modified With a Nanostructure Prepared From Titania Nanoparticles and Copper Oxide Publisher Pubmed



Ghanbari MH1, 2, 3 ; Shahdostfard F4, 5 ; Rostami M6 ; Khoshroo A7 ; Sobhaninasab A8, 9 ; Gholipour N1, 2 ; Salehzadeh H3 ; Ganjali MR10, 11 ; Rahiminasrabadi M1, 2 ; Ahmadi F12, 13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran
  2. 2. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, 19516-83759, Iran
  3. 3. Faculty of Chemistry, Kharazmi University, Tehran, 15719-14911, Iran
  4. 4. Department of Chemistry, University of Ilam, Ilam, 69315-45516, Iran
  5. 5. Faculty of Medicine, Ilam University of Medical Sciences, Ilam, 69391-77143, Iran
  6. 6. Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, 16987-39196, Iran
  7. 7. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 67346-67149, Iran
  8. 8. Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, 87196-57891, Iran
  9. 9. Core Research Lab, Kashan University of Medical Sciences, Kashan, 87196-57891, Iran
  10. 10. Center of Excellence in Electrochemistry, University of Tehran, Tehran, 19839-69411, Iran
  11. 11. Biosensor Research Centre, Endocrinology & Metabolism Molecular and Cellular Research Institute, Tehran University of Medical Sciences, Tehran, 19839-69411, Iran
  12. 12. Physiology Research Center, Iran University of Medical Sciences, Tehran, 14496-14535, Iran
  13. 13. Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, 14515-55763, Iran

Source: Microchimica Acta Published:2019


Abstract

A nanostructure was prepared from titania nanoparticles and copper oxide (TiO2NP@CuO) and used to modify a carbon paste electrode (CPE). The modified CPE is shown to enable sensitive voltammetric determination of the drug clozapine (CLZ). The sensor was characterized by various techniques and some key parameters were optimized. Under the optimum conditions and at a working potential of 0.6 V (vs. Ag/AgCl), the modified CPE has two linear response ranges, one from 30 pmol L−1 to 4 nmol L−1 of CLZ, the other from 4 nmol L−1 to 10 μmol L−1. The detection limit is as low as 9 pM. The transfer coefficient (α) and catalytic rate constant (kcat) were calculated and the reliability of the sensor was estimated for CLZ sensing in real samples where it gave satisfactory results. [Figure not available: see fulltext.]. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.
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