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An Electrochemical Sensor Based on Poly (L-Cysteine)@Aunps @ Reduced Graphene Oxide Nanocomposite for Determination of Levofloxacin Publisher



Ghanbari MH1, 2 ; Khoshroo A3 ; Sobati H4 ; Ganjali MR5, 6 ; Rahiminasrabadi M1, 2 ; Ahmadi F7, 8
Authors
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Authors Affiliations
  1. 1. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  4. 4. Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Center of Excellence in Electrochemistry, University of Tehran, Tehran, Iran
  6. 6. Biosensor Research Centre, Endocrinology & Metabolism Molecular and Cellular Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran

Source: Microchemical Journal Published:2019


Abstract

A novel electrochemical sensor has been developed for levofloxacin (LEV), by coating a glassy carbon electrode (GCE) with a film of poly (L-Cysteine)@Au NPs@reduced graphene oxide. Cyclic voltammetry, electrochemical impedance spectroscopy, UV–Vis spectroscopy, FT-IR spectroscopy and electron scanning microscope imaging were used for general surface characterization over the successive electrode modification steps. The electrochemical properties of the LEV was monitored by performing cyclic voltammetry (CV) experiments. The CVs showed one oxidation peak at 1.0 V during the anodic potential scan, which was attributed to LEV. Differential pulse voltammetry experiments using the modified electrode produced linear response in two concentration windows of 1.0 × 10 −11 M and 1.0 × 10 −4 (LEV), with detection limits of 3.0 × 10 −12 M for LEV. The GCE modified through coating with a film of poly(l-cys)/AuNPs/rGO/GCE was found to offer high stability, reproducibility, and repeatability, as well as selectivity for LEV in mixed samples, and was successfully used in the analysis of the LEV in synthetic blood serum, with recovery values of around 99%. © 2019 Elsevier B.V.
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