Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Chromium Supplementation on Apolipoproteins: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Shahinfar H1, 2 ; Amini MR1 ; Sheikhhossein F3 ; Djafari F1 ; Jafari A1 ; Shabbidar S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Clinical Nutrition ESPEN Published:2020


Abstract

Background: Apos play a role in lipoprotein metabolism. Several studies have been carried out on the effect of chromium supplement in improving CVD risk factors. Objective: This study is a systematic review and meta-analysis that aimed to investigate the effect of chromium supplementation on Apos levels of human studies. Materials and methods: We searched PubMed, Scopus up to May 2020 up to September 2019. We retrieved studies from identified articles. The studies’ quality was evaluated using Cochrane Risk of Bias Tool. We estimated the effect of chromium supplementation on Apo A, Apo A1, and Apo B by pooling mean and standard deviation (SD) values. Results: We obtained six trials involving 231 participants. Chromium consumption resulted significantly decreased Apo B while the subjects were ingesting chromium picolinate. Chromium supplementation did not significantly decrease Apo A (WMD: −3.89 mg/dl; 95% CI, −11.96 to 4.18) with no significant heterogeneity (I2 = 0.00%, p = 0.37). The serum level of Apo A1 did not statistically change following chromium intervention (WMD: 6.11 mg/dl; 95% CI, −7.01 to 19.23) with no significant heterogeneity (I2 = 0.00%, p = 0.68). Chromium supplementation did not significantly decrease Apo B (WMD: 3.81 mg/dl; 95% CI, −5.32 to 12.94). With no significant heterogeneity (I2 = 42.3%, p = 0.12). Conclusions: The chromium supplement did not have a significant effect on the Apolipoproteins (Apo A, ApoA1 and Apo B). © 2020 European Society for Clinical Nutrition and Metabolism
Experts (# of related papers)
Other Related Docs
19. Meal Replacements on Obesity and Leptin: A Systematic Review and Meta-Analysis, Reviews in Endocrine and Metabolic Disorders (2025)