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A Review on Advances in Graphene-Derivative/Polysaccharide Bionanocomposites: Therapeutics, Pharmacogenomics and Toxicity Publisher Pubmed



Makvandi P1, 2 ; Ghomi M3 ; Ashrafizadeh M4 ; Tafazoli A5 ; Agarwal T6 ; Delfi M7 ; Akhtari J8 ; Zare EN9 ; Padil VVT10 ; Zarrabi A11, 12 ; Pourreza N3 ; Miltyk W5 ; Maiti TK6
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Source: Carbohydrate Polymers Published:2020


Abstract

Graphene-based bionanocomposites are employed in several ailments, such as cancers and infectious diseases, due to their large surface area (to carry drugs), photothermal properties, and ease of their functionalization (owing to their active groups). Modification of graphene-derivatives with polysaccharides is a promising strategy to decrease their toxicity and improve target ability, which consequently enhances their biotherapeutic efficacy. Herein, functionalization of graphene-based materials with carbohydrate polymers (e.g., chitosan, starch, alginate, hyaluronic acid, and cellulose) are presented. Subsequently, recent advances in graphene nanomaterial/polysaccharide-based bionanocomposites in infection treatment and cancer therapy are comprehensively discussed. Pharmacogenomic and toxicity assessments for these bionanocomposites are also highlighted to provide insight for future optimized and smart investigations and researches. © 2020 Elsevier Ltd
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