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Graphene Oxide Nanoarchitectures in Cancer Therapy: Drug and Gene Delivery, Phototherapy, Immunotherapy, and Vaccine Development Publisher Pubmed



Sadeghi MS1 ; Sangrizeh FH2 ; Jahani N3 ; Abedin MS4 ; Chaleshgari S5 ; Ardakan AK3 ; Baeelashaki R6 ; Ranjbarpazuki G4 ; Rahmanian P3 ; Zandieh MA7 ; Nabavi N8 ; Aref AR9, 10 ; Salimimoghadam S11 ; Rashidi M12, 13 Show All Authors
Authors
  1. Sadeghi MS1
  2. Sangrizeh FH2
  3. Jahani N3
  4. Abedin MS4
  5. Chaleshgari S5
  6. Ardakan AK3
  7. Baeelashaki R6
  8. Ranjbarpazuki G4
  9. Rahmanian P3
  10. Zandieh MA7
  11. Nabavi N8
  12. Aref AR9, 10
  13. Salimimoghadam S11
  14. Rashidi M12, 13
  15. Rezaee A4
  16. Hushmandi K7
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Veterinary Medicine, Islamic Azad University, Babol Branch, Babol, Iran
  3. 3. Faculty of Veterinary Medicine, Islamic Azad University, Science and Research Branch, Tehran, Iran
  4. 4. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Avian Diseases, Faculty of Veterinary Medicine, Chamran University, Ahvaz, Iran
  6. 6. Department of Food Hygiene and Quality Control, Division of Animal Feed Hygiene, Faculty of Veterinary Medicine, Islamic Azad University, Shabestar Branch, Shabestar, Iran
  7. 7. Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  8. 8. Department of Urologic Sciences, University of British Columbia, Vancouver, V5Z 1M9, BC, Canada
  9. 9. Department of Cancer Biology, Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Department of Genetics, Harvard Medical School, Boston, MA, United States
  10. 10. Department of Translational Sciences, Xsphera Biosciences Inc. Boston, MA, United States
  11. 11. Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  12. 12. Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  13. 13. The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Source: Environmental Research Published:2023


Abstract

The latest advancements in oncology involves the creation of multifunctional nanostructures. The integration of nanoparticles into the realm of cancer therapy has brought about a transformative shift, revolutionizing the approach to addressing existing challenges and limitations in tumor elimination. This is particularly crucial in combating the emergence of resistance, which has significantly undermined the effectiveness of treatments like chemotherapy and radiotherapy. GO stands as a carbon-derived nanoparticle that is increasingly finding utility across diverse domains, notably in the realm of biomedicine. The utilization of GO nanostructures holds promise in the arena of oncology, enabling precise transportation of drugs and genetic material to targeted sites. GO nanomaterials offer the opportunity to enhance the pharmacokinetic behavior and bioavailability of drugs, with documented instances of these nanocarriers elevating drug accumulation at the tumor location. The GO nanostructures encapsulate genes, shielding them from degradation and facilitating their uptake within cancer cells, thereby promoting efficient gene silencing. The capability of GO to facilitate phototherapy has led to notable advancements in reducing tumor progression. By PDT and PTT combination, GO nanomaterials hold the capacity to diminish tumorigenesis. GO nanomaterials have the potential to trigger both cellular and innate immunity, making them promising contenders for vaccine development. Additionally, types of GO nanoparticles that respond to specific stimuli have been applied in cancer eradication, as well as for the purpose of cancer detection and biomarker diagnosis. Endocytosis serves as the mechanism through which GO nanomaterials are internalized. Given these advantages, the utilization of GO nanomaterials for tumor elimination comes highly recommended. © 2023 Elsevier Inc.
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