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Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces Publisher Pubmed



Hajipour MJ1, 2, 3 ; Ghasemi F4 ; Aghaverdi H2 ; Raoufi M2, 5 ; Linnef U6 ; Atyabi F2 ; Nabipour I1 ; Azhdarzadeh M2 ; Derakhshankhah H7 ; Lotfabadi A7 ; Bargahi A1 ; Alekhamis Z2 ; Aghaie A8 ; Hashemi E9 Show All Authors
Authors
  1. Hajipour MJ1, 2, 3
  2. Ghasemi F4
  3. Aghaverdi H2
  4. Raoufi M2, 5
  5. Linnef U6
  6. Atyabi F2
  7. Nabipour I1
  8. Azhdarzadeh M2
  9. Derakhshankhah H7
  10. Lotfabadi A7
  11. Bargahi A1
  12. Alekhamis Z2
  13. Aghaie A8
  14. Hashemi E9
  15. Tafakhori A10
  16. Aghamollaii V11
  17. Mashhadi MM10
  18. Sheibani S12
  19. Vali H12
  20. Mahmoudi M2
Show Affiliations
Authors Affiliations
  1. 1. Persian Gulf Marine Biotechnology Research Center, Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
  2. 2. Department of Nanotechnology and Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran
  3. 3. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  5. 5. Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany
  6. 6. Fachbereich Physik/Chemie, Philipps-Universitat Marburg, Marburg, Germany
  7. 7. Department of Pharmaceutical, Biomaterials and Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  9. 9. National Research Center for Transgenic Mouse, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  10. 10. Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Anatomy and Cell Biology, Facility for Electron Microscopy Research, McGill University, Montreal, H3A 0C7, QC, Canada

Source: Journal of Alzheimer's Disease Published:2017


Abstract

It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP complexes, obtained from different human serums, had distinct protein composition, including some specific proteins that are known as AD and MS biomarkers. The colorimetric responses, analyzed by chemometrics and statistical methods, demonstrate promising capabilities of the technology to unambiguously identify and discriminate AD and MS. The developed colorimetric technology might enable a simple, inexpensive and rapid detection/discrimination of neurodegenerative diseases. © 2017 - IOS Press and the authors.
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