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Protein Corona: Challenges and Opportunities for Cancer Therapy Publisher



Fateh ST1 ; Mehryab F2, 3 ; Fateh ST1 ; Salehinajafabadi A5, 6 ; Aref AR7, 8
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, ACECR, Iran
  4. 4. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiology, School of Biology, University College of Science, University of Tehran, Tehran, Iran
  6. 6. Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran
  7. 7. Belfer Center for Applied Cancer Science, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States
  8. 8. Xsphera Biosciences, Boston, MA, United States

Source: Functionalized Nanomaterials for Cancer Research: Applications in Treatments# Tools and Devices Published:2024


Abstract

Albeit nanoparticle (NP)-based therapeutics have gained immense recognition in recent years and extensive research has been conducted in this field, very few nanomedicines have been successfully translated into the clinical phase. This could be due to the altered performance of NPs in biological media in vivo. Absorption of biomolecules in biological media by NPs leads to protein corona formation, which modulates the biological performance of NPs and hence attenuates their desired therapeutic effects. Intrinsic physicochemical properties of NPs are determinative of corona formation and its composition. On the other hand, extrinsic parameters such as biological fluid characteristics are also fundamental in determining protein corona composition. Protein corona determines the sustainability and performance of NPs in drug loading, releasing, and cancer cell targeting. This chapter primarily discusses the challenges of utilizing NPs, the effect of protein corona on nanomedicine performance in cancer therapy, and opportunities to improve nanomedicine performance by protein corona engineering. Ultimately, personalized protein corona and its applications in cancer screening and diagnosis as a promising opportunity will be discussed. © 2024 Elsevier Inc. All rights reserved.
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