Shelterin Complex at Telomeres: Implications in Ageing

Shelterin Complex at Telomeres: Implications in Ageing Publisher Pubmed

Mir SM^{1, 3} ; Tehrani SS^{4, 5} ; Goodarzi G^{4, 5} ; Jamalpoor Z¹ ; Asadi J⁶ ; Khelghati N⁷ ; Qujeq D³ ; Maniati M⁸

Show Affiliations

1. Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran
2. Babol University of Medical Sciences, Babol, Iran
3. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
4. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
7. Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
8. School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Clinical Interventions in Aging Published:2020

Abstract

Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing. © 2020 Mir et al.

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Style	Citing Format
MLA	Mir SM, et al.. "Shelterin Complex at Telomeres: Implications in Ageing." Clinical Interventions in Aging, vol. 15, no. , 2020, pp. 827-839.
APA	Mir SM, Tehrani SS, Goodarzi G, Jamalpoor Z, Asadi J, Khelghati N, Qujeq D, Maniati M (2020). Shelterin Complex at Telomeres: Implications in Ageing. Clinical Interventions in Aging, 15(), 827-839.
Chicago	Mir SM, Tehrani SS, Goodarzi G, Jamalpoor Z, Asadi J, Khelghati N, Qujeq D, Maniati M. "Shelterin Complex at Telomeres: Implications in Ageing." Clinical Interventions in Aging 15, no. (2020): 827-839.
Harvard	Mir SM et al. (2020) 'Shelterin Complex at Telomeres: Implications in Ageing', Clinical Interventions in Aging, 15(), pp. 827-839.
Vancouver	Mir SM, Tehrani SS, Goodarzi G, Jamalpoor Z, Asadi J, Khelghati N, et al.. Shelterin Complex at Telomeres: Implications in Ageing. Clinical Interventions in Aging. 2020;15():827-839.
BibTex	@article{ author = {Mir SM and Tehrani SS and Goodarzi G and Jamalpoor Z and Asadi J and Khelghati N and Qujeq D and Maniati M}, title = {Shelterin Complex at Telomeres: Implications in Ageing}, journal = {Clinical Interventions in Aging}, volume = {15}, number = {}, pages = {827-839}, year = {2020} }
RIS	TY - JOUR AU - Mir SM AU - Tehrani SS AU - Goodarzi G AU - Jamalpoor Z AU - Asadi J AU - Khelghati N AU - Qujeq D AU - Maniati M TI - Shelterin Complex at Telomeres: Implications in Ageing JO - Clinical Interventions in Aging VL - 15 IS - SP - 827 EP - 839 PY - 2020 ER -

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