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Natural Products and the Balancing Act of Autophagy-Dependent/Independent Ferroptosis in Cancer Therapy Publisher Pubmed



Rahimipour Anaraki S1 ; Farzami P2 ; Hosseini Nasab SS3 ; Kousari A3 ; Fazlollahpour Naghibi A4 ; Shariat Zadeh M5 ; Barati R1 ; Taha SR5 ; Karimian A6 ; Nabiafjadi M7 ; Yousefi B6
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  5. 5. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Medicine, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Source: Naunyn-Schmiedeberg's Archives of Pharmacology Published:2024


Abstract

The control of biological cell death is essential for the body’s appropriate growth. The resistance of cells to the apoptotic process presents a new difficulty in the treatment of cancer. To combat cancer cells, researchers are working to find new apoptotic pathways and components to activate. One of the processes of regulated cell death (RCD) is referred to as ferroptosis marked by a decline in the activity of lipid glutathione peroxidase 4 (GPX4) after the buildup of reactive oxygen species (ROS). Since lipid peroxidation is a crucial component of ferroptosis and is required for its start, numerous medicines have been studied, particularly for the treatment of cancer. In this context, autophagy is an additional form of RCD that can govern ferroptosis through shared signaling pathways/factors involved in both mechanisms. In this review, we will explore the molecular mechanisms underlying ferroptosis and its association with autophagy, to gain fresh insights into their interplay in cancer advancement, and the potential of natural products for its treatment. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023.
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