A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines

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A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines Publisher

Peytam F¹ ; Adib M¹ ; Shourgeshty R¹ ; Rahmanianjazi M¹ ; Jahani M¹ ; Larijani B² ; Mahdavi M²

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1. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Tetrahedron Letters Published:2019

Abstract

An efficient, one-pot and three-component synthesis of a new series of 2-acyl-3,4,6-triaryl-1,4-dihydropyrazines is described. This two-step strategy involves treatment of phenacyl bromides and anilines to give the nucleophilic substitution intermediate followed by Michael-addition-cyclization to α-azidochalcones to afford the title compounds in high yields. © 2019 Elsevier Ltd

Style	Citing Format
MLA	Peytam F, et al.. "A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines." Tetrahedron Letters, vol. 60, no. 47, 2019, pp. -.
APA	Peytam F, Adib M, Shourgeshty R, Rahmanianjazi M, Jahani M, Larijani B, Mahdavi M (2019). A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines. Tetrahedron Letters, 60(47), -.
Chicago	Peytam F, Adib M, Shourgeshty R, Rahmanianjazi M, Jahani M, Larijani B, Mahdavi M. "A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines." Tetrahedron Letters 60, no. 47 (2019): -.
Harvard	Peytam F et al. (2019) 'A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines', Tetrahedron Letters, 60(47), pp. -.
Vancouver	Peytam F, Adib M, Shourgeshty R, Rahmanianjazi M, Jahani M, Larijani B, et al.. A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines. Tetrahedron Letters. 2019;60(47):-.
BibTex	@article{ author = {Peytam F and Adib M and Shourgeshty R and Rahmanianjazi M and Jahani M and Larijani B and Mahdavi M}, title = {A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines}, journal = {Tetrahedron Letters}, volume = {60}, number = {47}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Peytam F AU - Adib M AU - Shourgeshty R AU - Rahmanianjazi M AU - Jahani M AU - Larijani B AU - Mahdavi M TI - A One-Pot and Three-Component Synthetic Approach for the Preparation of Asymmetric and Multi-Substituted 1,4-Dihydropyrazines JO - Tetrahedron Letters VL - 60 IS - 47 SP - EP - PY - 2019 ER -

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Abstract