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Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions Publisher



Asgari MS1 ; Soheilizad M2 ; Ranjbar PR1 ; Larijani B3 ; Rahimi R4 ; Mahdavi M3
Authors

Source: Tetrahedron Letters Published:2019


Abstract

An efficient approach for the synthesis of N-alkyl-2-aryl-2-(6-oxo-4H-benzo[f][1,2,3]triazolo[1,5-a][1,4]diazepin-5(6H)-yl)acetamides is described. The protocol involves Ugi four-component reaction of 2-bromobenzoic acid, propargylamine, aldehydes and isocyanides followed by in situ sequential click reaction of azide ion with triple bond and N-arylation reaction to afford desired products in good to excellent yields. © 2019 Elsevier Ltd
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