Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions

Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions Publisher

Asgari MS¹ ; Soheilizad M² ; Ranjbar PR¹ ; Larijani B³ ; Rahimi R⁴ ; Mahdavi M³

Show Affiliations

1. School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
2. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Chemistry, Iran University of Science and Technology, Narmak, 16846-13114, Tehran, Iran

Source: Tetrahedron Letters Published:2019

Abstract

An efficient approach for the synthesis of N-alkyl-2-aryl-2-(6-oxo-4H-benzo[f][1,2,3]triazolo[1,5-a][1,4]diazepin-5(6H)-yl)acetamides is described. The protocol involves Ugi four-component reaction of 2-bromobenzoic acid, propargylamine, aldehydes and isocyanides followed by in situ sequential click reaction of azide ion with triple bond and N-arylation reaction to afford desired products in good to excellent yields. © 2019 Elsevier Ltd

Style	Citing Format
MLA	Asgari MS, et al.. "Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions." Tetrahedron Letters, vol. 60, no. 8, 2019, pp. 583-585.
APA	Asgari MS, Soheilizad M, Ranjbar PR, Larijani B, Rahimi R, Mahdavi M (2019). Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions. Tetrahedron Letters, 60(8), 583-585.
Chicago	Asgari MS, Soheilizad M, Ranjbar PR, Larijani B, Rahimi R, Mahdavi M. "Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions." Tetrahedron Letters 60, no. 8 (2019): 583-585.
Harvard	Asgari MS et al. (2019) 'Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions', Tetrahedron Letters, 60(8), pp. 583-585.
Vancouver	Asgari MS, Soheilizad M, Ranjbar PR, Larijani B, Rahimi R, Mahdavi M. Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions. Tetrahedron Letters. 2019;60(8):583-585.
BibTex	@article{ author = {Asgari MS and Soheilizad M and Ranjbar PR and Larijani B and Rahimi R and Mahdavi M}, title = {Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions}, journal = {Tetrahedron Letters}, volume = {60}, number = {8}, pages = {583-585}, year = {2019} }
RIS	TY - JOUR AU - Asgari MS AU - Soheilizad M AU - Ranjbar PR AU - Larijani B AU - Rahimi R AU - Mahdavi M TI - Novel and Efficient Synthesis of Triazolobenzodiazepine Analogues Through the Sequential Ugi 4Cr-Click-N-Arylation Reactions JO - Tetrahedron Letters VL - 60 IS - 8 SP - 583 EP - 585 PY - 2019 ER -

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