Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors

Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors

Rafinejad A¹ ; Fallahtafti A¹ ; Tiwari R² ; Shirazi AN² ; Mandal D² ; Parang K² ; Foroumadi A³ ; Akbarzadeh T^{1, 4}

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, 02881, RI, United States
3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Sciences# Islamic Republic of Iran Published:2015

Abstract

In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.

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Style	Citing Format
MLA	Rafinejad A, et al.. "Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors." Journal of Sciences# Islamic Republic of Iran, vol. 26, no. 4, 2015, pp. 321-325.
APA	Rafinejad A, Fallahtafti A, Tiwari R, Shirazi AN, Mandal D, Parang K, Foroumadi A, Akbarzadeh T (2015). Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors. Journal of Sciences# Islamic Republic of Iran, 26(4), 321-325.
Chicago	Rafinejad A, Fallahtafti A, Tiwari R, Shirazi AN, Mandal D, Parang K, Foroumadi A, Akbarzadeh T. "Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors." Journal of Sciences# Islamic Republic of Iran 26, no. 4 (2015): 321-325.
Harvard	Rafinejad A et al. (2015) 'Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors', Journal of Sciences# Islamic Republic of Iran, 26(4), pp. 321-325.
Vancouver	Rafinejad A, Fallahtafti A, Tiwari R, Shirazi AN, Mandal D, Parang K, et al.. Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors. Journal of Sciences# Islamic Republic of Iran. 2015;26(4):321-325.
BibTex	@article{ author = {Rafinejad A and Fallahtafti A and Tiwari R and Shirazi AN and Mandal D and Parang K and Foroumadi A and Akbarzadeh T}, title = {Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors}, journal = {Journal of Sciences# Islamic Republic of Iran}, volume = {26}, number = {4}, pages = {321-325}, year = {2015} }
RIS	TY - JOUR AU - Rafinejad A AU - Fallahtafti A AU - Tiwari R AU - Shirazi AN AU - Mandal D AU - Parang K AU - Foroumadi A AU - Akbarzadeh T TI - Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors JO - Journal of Sciences# Islamic Republic of Iran VL - 26 IS - 4 SP - 321 EP - 325 PY - 2015 ER -

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