Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Exploring the Polarization of M1 and M2 Macrophages in the Context of Skin Diseases Publisher Pubmed



Apeku E1 ; Tantuoyir MM3 ; Zheng R4 ; Tanye N5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Dermatology, The 1st Hospital of Shanxi Medical University
  2. 2. Graduate Department of Shanxi Medical University, Shanxi, Taiyuan, China
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Dermatology, The 1st Hospital of Shanxi Medical University, Shanxi, Taiyuan, China
  5. 5. School of Automation Science and Engineering, Xi’an Jiaotong University, Xi’an, China

Source: Molecular Biology Reports Published:2024


Abstract

Macrophages are critical components of the immune system and play vital roles in pathogen defense, immune regulation, and tissue repair. These cells exhibit different polarization states depending on environmental signals, and the M1/M2 paradigm is a useful tool for comprehending these states. This review article comprehensively presents the underlying mechanisms of M1 and M2 macrophage polarization and examines their polarization in various skin diseases. Additionally, this paper discusses therapeutic strategies that target M1 and M2 macrophage polarization in skin diseases. A more profound understanding of macrophage polarization in skin diseases could provide valuable insights for the development of innovative therapeutic strategies. © 2024, The Author(s), under exclusive licence to Springer Nature B.V.
Related Docs
View other Related Docs
1. A Narrative Review of Tumor-Associated Macrophages in Lung Cancer: Regulation of Macrophage Polarization and Therapeutic Implications, Translational Lung Cancer Research (2021)
2. Modulation of Macrophage Polarization for Bone Tissue Engineering Applications, Iranian Journal of Allergy# Asthma and Immunology (2018)
3. The Sdldl Reduces Mrc1 Expression Level and Secretion of Histamin E in Differentiated M2-Macrophages From Patients With Coronary Artery Stenosis, Cardiovascular and Hematological Disorders - Drug Targets (2017)
4. Unfulfilled Inflammatory Resolution: A Key Factor in the Pathogenesis of Psoriasis, Iranian Journal of Allergy# Asthma and Immunology (2020)
5. A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer, Current Drug Targets (2019)
6. A2a Adenosine Receptor Agonist Reduced Mmp8 Expression in Healthy M2-Like Macrophages But Not in Macrophages From Ankylosing Spondylitis Patients; [Authors and Affiliations], BMC Musculoskeletal Disorders (2022)
7. Diabetes As One of the Long-Term Covid-19 Complications: From the Potential Reason of More Diabetic Patients’ Susceptibility to Covid-19 to the Possible Caution of Future Global Diabetes Tsunami, Inflammopharmacology (2023)
8. Macrophage Repolarization Using Cd44-Targeting Hyaluronic Acid–Polylactide Nanoparticles Containing Curcumin, Artificial Cells# Nanomedicine and Biotechnology (2018)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (1)
Nima Rezaei (1)
Other Related Docs
9. Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects, Current Pharmaceutical Design (2019)