A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer

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A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer Publisher Pubmed

Seif F^{1, 2} ; Sharifi L³ ; Khoshmirsafa M^{1, 2} ; Mojibi Y⁴ ; Mohsenzadegan M⁴

Show Affiliations

1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
3. Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: Current Drug Targets Published:2019

Abstract

Prostate cancer is malignant cancer leading to high mortality in the male population. The existence of suppressive cells referred to as tumor-associated macrophages (TAM) is a major obstacle in prostate cancer immunotherapy. TAMs contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. In fact, they are main regulators of the complicated interactions between tumor and surrounding microenvironment. M2 macrophages, as a type of TAMs, are involved in the growth and progression of prostate cancer. Recently, they have gained remarkable importance as therapeutic candidates for solid tumors. In this review, we will discuss the roles of M2 macrophages and worth of their potential targeting in prostate cancer treatment. In the following, we will introduce important factors resulting in M2 macrophage promotion and also experimental therapeutic agents that may cause the inhibition of prostate cancer tumor growth. © 2019 Bentham Science Publishers.

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Style	Citing Format
MLA	Seif F, et al.. "A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer." Current Drug Targets, vol. 20, no. 7, 2019, pp. 789-798.
APA	Seif F, Sharifi L, Khoshmirsafa M, Mojibi Y, Mohsenzadegan M (2019). A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer. Current Drug Targets, 20(7), 789-798.
Chicago	Seif F, Sharifi L, Khoshmirsafa M, Mojibi Y, Mohsenzadegan M. "A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer." Current Drug Targets 20, no. 7 (2019): 789-798.
Harvard	Seif F et al. (2019) 'A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer', Current Drug Targets, 20(7), pp. 789-798.
Vancouver	Seif F, Sharifi L, Khoshmirsafa M, Mojibi Y, Mohsenzadegan M. A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer. Current Drug Targets. 2019;20(7):789-798.
BibTex	@article{ author = {Seif F and Sharifi L and Khoshmirsafa M and Mojibi Y and Mohsenzadegan M}, title = {A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer}, journal = {Current Drug Targets}, volume = {20}, number = {7}, pages = {789-798}, year = {2019} }
RIS	TY - JOUR AU - Seif F AU - Sharifi L AU - Khoshmirsafa M AU - Mojibi Y AU - Mohsenzadegan M TI - A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer JO - Current Drug Targets VL - 20 IS - 7 SP - 789 EP - 798 PY - 2019 ER -

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