Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Immunomodulation in Systemic Lupus Erythematosus: Induction of M2 Population in Monocyte-Derived Macrophages by Pioglitazone Publisher Pubmed



Mohammadi S1 ; Saghaeianjazi M2 ; Sedighi S3 ; Memarian A4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Biochemistry and Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Joint, Bone and Connective Tissue Research Center (JBCRC), Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran

Source: Lupus Published:2017


Abstract

Macrophages have recently gained attention in systemic lupus erythematosus (SLE) pathogenesis for their role in the anti-inflammatory clearance of apoptotic cells. The M1/M2 polarization of macrophages improves efferocytic capability. Peroxisome proliferator-activated receptor I3 is proposed to function in the expansion of the M2 subpopulation. Pioglitazone is a peroxisome proliferator-activated receptor I3 agonist with a variety of anti-inflammatory effects. In this paper, we investigated the ex vivo alterations of monocyte-derived macrophages of 15 newly diagnosed SLE patients and 10 normal subjects triggered by apoptotic cells among SLE patients following pioglitazone treatment. The phagocytosis capacity of macrophages and M1/M2 polarization (CD86/CD163) was evaluated. The supernatants were also analyzed for the expression of interleukin (IL)-10, IL-12, transforming growth factor β1 and TNF-α. The mRNA expression of IL-1β and mannose receptor C-type 1 were also quantified among treated and non-treated monocyte-derived macrophages. We found that efferocytosis is defective among monocyte-derived macrophages of SLE patients and might be a major underlying mechanism involved in the sustained inflammation. Pioglitazone could enhance alternative activation of monocyte-derived macrophages and consequently immunomodulation in these patients. © 2017 Author(s).
Related Docs
View other Related Docs
1. Effect of Efferocytosis of Apoptotic Mesenchymal Stem Cells (Mscs) on C57bl/6 Peritoneal Macrophages Function, Life Sciences (2018)
2. Modulation of Macrophage Polarization for Bone Tissue Engineering Applications, Iranian Journal of Allergy# Asthma and Immunology (2018)
3. Don't Eat Me/Eat Me Signals As a Novel Strategy in Cancer Immunotherapy, Heliyon (2023)
4. The Sdldl Reduces Mrc1 Expression Level and Secretion of Histamin E in Differentiated M2-Macrophages From Patients With Coronary Artery Stenosis, Cardiovascular and Hematological Disorders - Drug Targets (2017)
5. A Review on the Role of M2 Macrophages in Bladder Cancer; Pathophysiology and Targeting, International Immunopharmacology (2019)
6. The Role of Inflammatory Cytokines and Tumor Associated Macrophages (Tams) in Microenvironment of Pancreatic Cancer, Cytokine and Growth Factor Reviews (2018)
7. Immune Landscape of Hepatocellular Carcinoma: From Dysregulation of the Immune Responses to the Potential Immunotherapies, Cell Biochemistry and Function (2024)
8. A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer, Current Drug Targets (2019)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Laleh Sharifi (2)
Other Related Docs
9. Fractalkine Receptor Deficiency Is Associated With Early Protection But Late Worsening of Outcome Following Brain Trauma in Mice, Journal of Neurotrauma (2016)
10. Effect of Indole-3-Carbinol on Transcriptional Profiling of Wound-Healing Genes in Macrophages of Systemic Lupus Erythematosus Patients: An Rna Sequencing Assay, Lupus (2020)