In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives

In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives

Ramazani A¹ ; Hamidnezhad R¹ ; Foroumadi A² ; Mirzaei SA¹ ; Maddahi S³ ; Hassanzadeh SM⁴

Show Affiliations

1. Dept. of Biotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
2. Dept. of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Iranian Blood Transfusion Organization, Zanjan, Iran
4. BCG Vaccine Unit, Pasteur Institute of Iran, Tehran, Iran

Source: Iranian Journal of Parasitology Published:2016

Abstract

Background: Aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. This study investigated some new aurones derivatives against chloroquine sensitive Plasmodium falciparum. Here we report the synthesis, in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (Z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2H)- one. Methods: The cytotoxic evaluations of active compounds were performed with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay on human breast cancer cell lines; MCF7 and T47D. Results: From 11 compounds M3, M6 and M7 compounds showed good antiplasmodial effect against chloroquine-sensitive 3D strain of P. falciparum with IC50 (50% inhibitory concentration) values of 7.82, 7.27 and 2.3 μM respectively. No noticeable toxicity was observed with these compounds when tested against tested cell lines. Conclusion: The replacement of the 4 and 5 positions at ring B of aurone derivatives, with propoxy and bromide (Br) respectively was revealed highly advantageous for their antiplasmodial effect. © 2016, Tehran University of Medical Sciences (TUMS). All rights reserved.

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Style	Citing Format
MLA	Ramazani A, et al.. "In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives." Iranian Journal of Parasitology, vol. 11, no. 3, 2016, pp. 371-376.
APA	Ramazani A, Hamidnezhad R, Foroumadi A, Mirzaei SA, Maddahi S, Hassanzadeh SM (2016). In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives. Iranian Journal of Parasitology, 11(3), 371-376.
Chicago	Ramazani A, Hamidnezhad R, Foroumadi A, Mirzaei SA, Maddahi S, Hassanzadeh SM. "In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives." Iranian Journal of Parasitology 11, no. 3 (2016): 371-376.
Harvard	Ramazani A et al. (2016) 'In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives', Iranian Journal of Parasitology, 11(3), pp. 371-376.
Vancouver	Ramazani A, Hamidnezhad R, Foroumadi A, Mirzaei SA, Maddahi S, Hassanzadeh SM. In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives. Iranian Journal of Parasitology. 2016;11(3):371-376.
BibTex	@article{ author = {Ramazani A and Hamidnezhad R and Foroumadi A and Mirzaei SA and Maddahi S and Hassanzadeh SM}, title = {In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives}, journal = {Iranian Journal of Parasitology}, volume = {11}, number = {3}, pages = {371-376}, year = {2016} }
RIS	TY - JOUR AU - Ramazani A AU - Hamidnezhad R AU - Foroumadi A AU - Mirzaei SA AU - Maddahi S AU - Hassanzadeh SM TI - In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2- Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives JO - Iranian Journal of Parasitology VL - 11 IS - 3 SP - 371 EP - 376 PY - 2016 ER -

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