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Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives As Cytotoxic Agents



Firoozpour L1 ; Mokhtari A1 ; Moghimi S1 ; Safavi M2 ; Foroumadi A3, 4
Authors
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Authors Affiliations
  1. 1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, 33535-111, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Sciences# Islamic Republic of Iran Published:2018

Abstract

Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, biologically evaluated against breast cancer cell line (T47D) and compared with etoposide as a reference drug. The anticancer activities were evaluated by MTT colorimetric assay. Among all tested compounds, N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)acetamide illustrated the most potent cytotoxic activity. © 2018 National Research Center of Medical Sciences. All rights reserved.
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