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The Effects of Smoking on Treatment Outcome in Patients Newly Diagnosed With Pulmonary Tuberculosis Publisher Pubmed



Masjedi MR1 ; Hosseini M2 ; Aryanpur M3 ; Mortaz E4 ; Tabarsi P5 ; Soori H6 ; Emami H2 ; Heidari G2 ; Dizagie MK7 ; Baikpour M2
Authors
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Authors Affiliations
  1. 1. Shahid Beheshti University of Medical Sciences, Next to Ayatollah Taleghani Hospital, Evin, Tehran, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Tobacco Prevention and Control Research Centre, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Division of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, Netherlands
  5. 5. Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Safety Promotion and Injury Prevention Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Mycobacteriology Research Center, Biostatistics Unit, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Tuberculosis and Lung Disease Published:2017


Abstract

S E T T ING: Smoking is reported to be associated with tuberculosis (TB), but its effect on sputum smear conversion remains a matter for discussion. OBJ E C T I V E : To assess the effects of smoking and smoking cessation on treatment outcomes in patients newly diagnosed with TB in Iran. DESIGN: Newly diagnosed smear-positive TB patients were included in the study. All smokers participated in a smoking cessation programme. Sputum smear status was evaluated at the end of month 2, 5 and 6 of treatment, and smoking status was evaluated at the end of month 2. Differences in smear conversion rates were compared between the three groups, i.e., non-smokers, smokers and quitters. RESULT S : A total of 183 smokers and 151 non-smokers were included. When smoking cessation was assessed after 2 months, 42.6% (78/183) of the smokers were found to have quit. The cure rate at the end of 6 months, precisely compatible with the conversion rate, was significantly higher among non-smokers (P 0.004) and quitters at 2 months (P 0.049) than among persisting smokers (83.4%, 80.8% and 67.6%, respectively). CONCLUS ION: Cure rates in patients newly diagnosed with pulmonary TB were higher in non-smokers and quitters at 2 months than in smokers. Smoking cessation advice should be included in TB control programmes. © 2017 The Union.
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